Cited 25 times in
Involvement of IL-10 gene promoter polymorphisms in the susceptibility for childhood asthma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경원 | - |
dc.contributor.author | 김규언 | - |
dc.contributor.author | 김미나 | - |
dc.contributor.author | 손명현 | - |
dc.contributor.author | 이경은 | - |
dc.contributor.author | 허원일 | - |
dc.contributor.author | 홍정연 | - |
dc.date.accessioned | 2014-12-20T16:57:59Z | - |
dc.date.available | 2014-12-20T16:57:59Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0341-2040 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93715 | - |
dc.description.abstract | Asthma and atopy have a complex background that may result from the interaction of genes and the environment. Interleukin (IL)-10 is known to play various roles in immune-regulating and anti-inflammatory responses. The aim of this study was to evaluate the possible effect of the IL-10 promoter polymorphisms on susceptibility to childhood asthma. We recruited 333 patients with atopic asthma, 55 with nonatopic asthma, and 248 normal controls. We performed a genetic association study of three genetic polymorphisms (IL-10 -1082A>G, IL-10 -819T>C, and IL-10 -592A>C) of the IL-10 promoter. There was no difference between atopic asthma, nonatopic asthma, and normal controls with respect to allele, genotype, or haplotype frequencies of these IL-10 polymorphisms. However, the -1082A>G polymorphism and ATA haplotype in the IL-10 promoter gene were associated with airway hyper responsiveness (AHR) and the -819T>C, -592A>C, and ATA and ACC haplotypes were also shown to be related to serum eosinophil cationic protein (ECP). Our results suggest that the polymorphisms within the IL-10 promoter may have a disease-modifying effect in the asthmatic airway. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 417~423 | - |
dc.relation.isPartOf | LUNG | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Asthma/genetics* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Eosinophil Cationic Protein/genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Association Studies | - |
dc.subject.MESH | Genetic Predisposition to Disease/genetics* | - |
dc.subject.MESH | Haplotypes | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-10/genetics* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Promoter Regions, Genetic* | - |
dc.title | Involvement of IL-10 gene promoter polymorphisms in the susceptibility for childhood asthma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Kyung Won Kim | - |
dc.contributor.googleauthor | Kyung Eun Lee | - |
dc.contributor.googleauthor | Jung Yeon Hong | - |
dc.contributor.googleauthor | Mi Na Kim | - |
dc.contributor.googleauthor | Won Il Heo | - |
dc.contributor.googleauthor | Myung Hyun Sohn | - |
dc.contributor.googleauthor | Kyu-Earn Kim | - |
dc.identifier.doi | 10.1007/s00408-011-9312-5 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01967 | - |
dc.contributor.localId | A04361 | - |
dc.contributor.localId | A04431 | - |
dc.contributor.localId | A00303 | - |
dc.contributor.localId | A00327 | - |
dc.contributor.localId | A00441 | - |
dc.relation.journalcode | J02173 | - |
dc.identifier.eissn | 1432-1750 | - |
dc.identifier.pmid | 21779975 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00408-011-9312-5 | - |
dc.subject.keyword | Asthma | - |
dc.subject.keyword | Child | - |
dc.subject.keyword | Polymorphism | - |
dc.subject.keyword | Genetic | - |
dc.subject.keyword | Interleukin-10 | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.alternativeName | Kim, Kyu Earn | - |
dc.contributor.alternativeName | Kim, Mina | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.alternativeName | Lee, Kyung Eun | - |
dc.contributor.alternativeName | Heo, Won Il | - |
dc.contributor.alternativeName | Hong, Jung Yeon | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Heo, Won Il | - |
dc.contributor.affiliatedAuthor | Hong, Jung Yeon | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Earn | - |
dc.contributor.affiliatedAuthor | Kim, Mina | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 189 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 417 | - |
dc.citation.endPage | 423 | - |
dc.identifier.bibliographicCitation | LUNG, Vol.189(5) : 417-423, 2011 | - |
dc.identifier.rimsid | 28413 | - |
dc.type.rims | ART | - |
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