0 57

Cited 4 times in

Reciprocal interactions of Fgf10/Fgfr2b modulate the mouse tongue epithelial differentiation

Authors
 Wern-Joo Sohn ; Hye-In Jung ; Jae-Young Kim ; Han-Sung Jung ; Hong-In Shin ; Eui-Kyun Park ; Zae Young Ryoo ; Sanggyu Lee ; Hitoshi Yamamoto ; Gi-Jeong Gwon ; Jin-Hyun Han ; Min-A Choi 
Citation
 Cell and Tissue Research, Vol.345(2) : 265~273, 2011 
Journal Title
 Cell and Tissue Research 
ISSN
 0302-766X 
Issue Date
2011
Abstract
The molecular mechanisms for epithelial differentiation have been studied by observing skin development in embryogenesis, but the early signaling modulations involved in tongue epithelial differentiation are not completely understood. Based on the gene expression patterns of the Fgf signaling molecules and previous results from Fgf10 and Fgfr2b knockout mice, it was hypothesized that there would be fundamental signaling interactions through the epithelial Fgfr2b and its mesenchymal ligand Fgf10 to regulate tongue epithelium differentiation. To elucidate these reciprocal interactions in tongue epithelial differentiation, this study employed an in vitro tongue organ culture system with antisense-oligodeoxynucleotides (AS-ODNs) and recombinant protein-soaked bead implantation for the loss-of-function and gain-of-function studies. Functional analysis of Fgf signaling revealed precise reciprocal interactions, which showed that mesenchymal Fgf10 rather than Fgf7 modulates tongue epithelial differentiation via Fgfr2b in a temporal- and spatial-specific manner.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93635
DOI
10.1007/s00441-011-1204-8
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://link.springer.com/article/10.1007%2Fs00441-011-1204-8
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse