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Reciprocal interactions of Fgf10/Fgfr2b modulate the mouse tongue epithelial differentiation

Authors
 Wern-Joo Sohn  ;  Hye-In Jung  ;  Min-A Choi  ;  Jin-Hyun Han  ;  Gi-Jeong Gwon  ;  Hitoshi Yamamoto  ;  Sanggyu Lee  ;  Zae Young Ryoo  ;  Eui-Kyun Park  ;  Hong-In Shin  ;  Han-Sung Jung  ;  Jae-Young Kim 
Citation
 CELL AND TISSUE RESEARCH, Vol.345(2) : 265-273, 2011 
Journal Title
 CELL AND TISSUE RESEARCH 
ISSN
 0302-766X 
Issue Date
2011
MeSH
Animals ; Cell Differentiation/physiology ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Fibroblast Growth Factor 10/genetics ; Fibroblast Growth Factor 10/metabolism* ; Mice ; Mice, Inbred ICR ; Mice, Knockout ; Receptor, Fibroblast Growth Factor, Type 2/genetics ; Receptor, Fibroblast Growth Factor, Type 2/metabolism* ; Signal Transduction ; Tongue/cytology* ; Tongue/metabolism*
Keywords
Fgfr2b ; Fgf10 ; Epithelial differentiation ; Epithelial–mesenchymal interactions ; Signaling modulations ; Mouse (ICR)
Abstract
The molecular mechanisms for epithelial differentiation have been studied by observing skin development in embryogenesis, but the early signaling modulations involved in tongue epithelial differentiation are not completely understood. Based on the gene expression patterns of the Fgf signaling molecules and previous results from Fgf10 and Fgfr2b knockout mice, it was hypothesized that there would be fundamental signaling interactions through the epithelial Fgfr2b and its mesenchymal ligand Fgf10 to regulate tongue epithelium differentiation. To elucidate these reciprocal interactions in tongue epithelial differentiation, this study employed an in vitro tongue organ culture system with antisense-oligodeoxynucleotides (AS-ODNs) and recombinant protein-soaked bead implantation for the loss-of-function and gain-of-function studies. Functional analysis of Fgf signaling revealed precise reciprocal interactions, which showed that mesenchymal Fgf10 rather than Fgf7 modulates tongue epithelial differentiation via Fgfr2b in a temporal- and spatial-specific manner.
Full Text
http://link.springer.com/article/10.1007%2Fs00441-011-1204-8
DOI
10.1007/s00441-011-1204-8
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93635
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