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Distinguishing hemangiomas from malignant solid hepatic lesions: a comparison of heavily T2-weighted images obtained before and after administration of gadoxetic acid.

Authors
 Sung Jun Ahn  ;  Myeong-Jin Kim  ;  Hye-Suk Hong  ;  Kyung Ah Kim  ;  Ho-Taek Song 
Citation
 JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.34(2) : 310-317, 2011 
Journal Title
 JOURNAL OF MAGNETIC RESONANCE IMAGING 
ISSN
 1053-1807 
Issue Date
2011
MeSH
Adult ; Aged ; Aged, 80 and over ; Contrast Media/pharmacology ; Diagnostic Imaging/methods ; Female ; Gadolinium DTPA/pharmacology* ; Hemangioma/pathology* ; Humans ; Image Processing, Computer-Assisted/methods ; Liver Neoplasms/diagnosis* ; Liver Neoplasms/pathology* ; Male ; Medical Oncology/methods ; Middle Aged ; Predictive Value of Tests ; ROC Curve
Keywords
heavily T2-weighted image ; magnetic reso-nance imaging ; hemangioma ; gadoxetic acid disodium ; hepatic lesion
Abstract
PURPOSE: To compare the use of heavily T2-weighted images obtained before and after administration of gadoxetic acid in differentiating hemangiomas from malignant solid hepatic lesions. MATERIALS AND METHODS: Heavily T2-weighted images (TE=150 msec) were obtained for 70 patients (42 men and 28 women) with 74 focal hepatic lesions (25 hepatocellular carcinomas [HCC], 22 metastases, and 27 hemangiomas) ≤3 cm in diameter before and after gadoxetic acid-enhanced dynamic magnetic resonance imaging (MRI). Quantitative analysis was performed using receiver operating characteristic (ROC) curves with lesion-to-liver signal intensity difference-to-noise ratio (SDNR) on precontrast and postcontrast images. Qualitative analysis was also performed by two blinded reviewers. RESULTS: The SDNR of the solid lesions was significantly higher on the postcontrast (1.66 ± 1.18) than on the precontrast (1.38 ± 1.07) images (P=0.0012), while the SDNR of hemangiomas was comparable for pre- and postcontrast images (P=0.8164). The best SDNR cutoff values for distinguishing solid lesions from hemangiomas were ≤1.85 (Az=0.948) for precontrast and ≤2.58 (Az=0.901) for postcontrast images (P=0.057). Reader performances for distinguishing hemangiomas from solid lesions were comparable between the precontrast (Az=0.975 and 0.970 for readers 1 and 2) and postcontrast (Az=0.977 and 0.972) images (P=0.899 and 0.946). CONCLUSION: Heavily T2-weighted images obtained after administration of gadoxetic acid have a diagnostic capability comparable to precontrast images for differentiating between small hemangiomas and malignant solid lesions of the liver.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jmri.22658/abstract
DOI
10.1002/jmri.22658
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
Ahn, Sung Jun(안성준) ORCID logo https://orcid.org/0000-0003-0075-2432
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93596
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