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Dextran-coated magnetic nanoclusters as highly sensitive contrast agents for magnetic resonance imaging of inflammatory macrophages

Authors
 Eun-Kyung Lim  ;  Eunji Jang  ;  Bongjune Kim  ;  Jihye Choi  ;  Kwangyeol Lee  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 Journal of Materials Chemistry, Vol.21 : 12473-12478, 2011 
Journal Title
 Journal of Materials Chemistry 
ISSN
 0959-9428 
Issue Date
2011
Abstract
We fabricated dextran-coated magnetic nanoclusters (Dex-MNCs) for targeted magnetic resonance (MR) imaging of inflammatory macrophages. Dex-MNCs were prepared through encapsulation of hydrophobic magnetic nanocrystals (MNCs) by pyrenyl dextran in order that MNCs could achieve increased colloidal stability in aqueous phase as well as strongly interact with macrophages. Dex-MNCs exhibited biocompatibility and sufficient targeting efficiency against macrophages with strengthened MR contrast effect from in vitro/in vivo studies. Considering these results, we confirmed that Dex-MNCs could accurately detect inflammatory macrophagevia MR imaging.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93560
Full Text
http://pubs.rsc.org/en/content/articlelanding/2011/jm/c1jm10764j#!divAbstract
DOI
10.1039/C1JM10764J
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
서진석(Suh, Jin Suck)
허용민(Huh, Yong Min)
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