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Venom peptides from solitary hunting wasps induce feeding disorder in lepidopteran larvae

Authors
 Ji Hyeong Baek ; Yeounjung Ji ; Si Hyeock Lee ; Seunghwan Lee ; Jeon-Soo Shin 
Citation
 Peptides, Vol.32(3) : 568~572, 2011 
Journal Title
 Peptides 
ISSN
 0196-9781 
Issue Date
2011
Abstract
The cell lytic activity and toxicity against lepidopteran larvae of 13 venom peptides (4 OdVPs and 9 EpVPs) from two solitary hunting wasps, Orancistrocerus drewseni and Eumenes pomiformis, were examined with mastoparan as a reference peptide. Of the 13 peptides, 7 were predicted to have α-helical structures that exhibit the typical character of amphipathic α-helical antimicrobial peptides. The remaining peptides exhibited coil structures; among these, EpVP5 possesses two Cys residues that form an internal disulfide bridge. All the helical peptides including mastoparan showed antimicrobial and insect cell lytic activities, whereas only two of them were hemolytic against human erythrocytes. The helical peptides induced a feeding disorder when injected into the vicinity of the head and thorax of Spodoptera exigua larvae, perhaps because their non-specific neurotoxic or myotoxic action induced cell lysis. At low concentrations, however, these helical peptides increased cell permeability without inducing cell lysis. These findings suggest that the helical venom peptides may function as non-specific neurotoxins or myotoxins and venom-spreading factors at low concentrations, as well as preservatives for long-term storage of the prey via antimicrobial, particularly antifungal, activities
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93531
DOI
10.1016/j.peptides.2010.12.007
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0196978110005358
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