1 143

Reversible SUMOylation of TBL1-TBLR1 regulates β-catenin-mediated Wnt signaling.

Authors
 Hyo-Kyoung Choi  ;  Kyung-Chul Choi  ;  Jung-Yoon Yoo  ;  Meiying Song  ;  Suk Jin Ko  ;  Chul Hoon Kim  ;  Jin-Hyun Ahn  ;  Kyung-Hee Chun  ;  Jong In Yook  ;  Ho-Geun Yoon 
Citation
 Molecular Cell, Vol.43(2) : 203-216, 2011 
Journal Title
 Molecular Cell 
ISSN
 1097-2765 
Issue Date
2011
Abstract
Dysregulation of Wnt signaling has been implicated in tumorigenesis. The role of Transducin β-like proteins TBL1-TBLR1 in the promotion of Wnt/β-catenin-mediated oncogenesis has recently been emphasized; however, the molecular basis of activation of Wnt signaling by the corepressor TBL1-TBLR1 is incompletely understood. Here, we show that both TBL1 and TBLR1 are SUMOylated in a Wnt signaling-dependent manner, and that this modification is selectively reversed by SUMO-specific protease I (SENP1). SUMOylation dismissed TBL1-TBLR1 from the nuclear hormone receptor corepressor (NCoR) complex, increased recruitment of the TBL1-TBLR1-β-catenin complex to the promoter of Wnt target genes, and consequently led to activation of Wnt signaling. Conversely, SENP1 decreased formation of the TBL1-TBLR1-β-catenin complex, leading to inhibition of β-catenin-mediated transcription. Importantly, inhibition of SUMOylation significantly decreased the tumorigenicity of SW480 colon cancer cells. Thus, our data reveal a mechanism for activation of Wnt signaling via the SUMOylation-dependent disassembly of the corepressor complex.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93487
Full Text
http://www.sciencedirect.com/science/article/pii/S1097276511004242
DOI
10.1016/j.molcel.2011.05.027
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
Yonsei Authors
김철훈(Kim, Chul Hoon) ORCID logo https://orcid.org/0000-0002-7360-429X
유정윤(Yoo, Jung Yoon) ORCID logo https://orcid.org/0000-0001-9366-3863
육종인(Yook, Jong In) ORCID logo https://orcid.org/0000-0002-7318-6112
윤호근(Yoon, Ho Geun) ORCID logo https://orcid.org/0000-0003-2718-3372
최경철(Choi, Kyung Chul)
최효경(Choi, Hyo Kyoung)
Export
RIS (EndNote)
XLS (Excel)
XML
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse