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The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects

Authors
 Yun-Young Chang  ;  Surangi Dissanayake  ;  Jeong-Ho Yun  ;  Ui-Won Jung  ;  Chang-Sung Kim  ;  Kyeong-Jun Park  ;  Jung-Kiu Chai  ;  Seong-Ho Choi 
Citation
 JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.41(3) : 123-130, 2011 
Journal Title
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
ISSN
 2093-2278 
Issue Date
2011
MeSH
Animals ; Bone Regeneration ; Calcium ; Calcium Phosphates ; Collagen ; Cyanoacrylates ; Hydroxyapatites ; Membranes ; Osteogenesis ; Porifera ; Rabbits
Keywords
Octylcyanoacrylate ; Calcium phosphate ; Rabbits ; Bone regeneration
Abstract
PURPOSE: The purpose of this study was to determine the biological effects of cyanoacrylate-combined calcium phosphate (CCP), in particular its potential to act as a physical barrier - functioning like a membrane - in rabbit calvarial defects.

METHODS: In each animal, four circular calvarial defects with a diameter of 8 mm were prepared and then filled with either nothing (control group) or one of three different experimental materials. In the experimental conditions, they were filled with CCP alone (CCP group), filled with biphasic calcium phosphate (BCP) and then covered with an absorbable collagen sponge (ACS; BCP/ACS group), or filled with BCP and then covered by CCP (BCP/CCP group).

RESULTS: After 4 and 8 weeks of healing, new bone formation appeared to be lower in the CCP group than in the control group, but the difference was not statistically significant. In both the CCP and BCP/CCP groups, inflammatory cells could be seen after 4 and 8 weeks of healing.

CONCLUSIONS: Within the limits of this study, CCP exhibited limited osteoconductivity in rabbit calvarial defects and was histologically associated with the presence of inflammatory cells. However, CCP demonstrated its ability to stabilize graft particles and its potential as an effective defect filler in bone augmentation, if the biocompatibility and osteoconductivity of CCP were improved.
Files in This Item:
T201101925.pdf Download
DOI
10.5051/jpis.2011.41.3.123
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Yun, Jeong Ho(윤정호)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Chai, Jung Kyu(채중규)
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93416
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