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Diagnostic performances of HE4 and CA125 for the detection of ovarian cancer from patients with various gynecologic and non-gynecologic diseases.

Authors
 Yongjung Park  ;  Jong-Han Lee  ;  Duck Jin Hong  ;  Eun Young Lee  ;  Hyon-Suk Kim 
Citation
 CLINICAL BIOCHEMISTRY, Vol.44(10-11) : 884-888, 2011 
Journal Title
CLINICAL BIOCHEMISTRY
ISSN
 0009-9120 
Issue Date
2011
MeSH
CA-125 Antigen/blood* ; Diagnosis, Differential ; Epididymal Secretory Proteins*/metabolism ; Female ; Humans ; Ovarian Neoplasms/blood* ; Ovarian Neoplasms/diagnosis* ; ROC Curve ; beta-Defensins
Keywords
Human epididymal secretory protein E4 ; CA125 ; Ovarian cancer ; Tumor markers
Abstract
OBJECTIVES: We compared diagnostic performance of CA125 and HE4 in various gynecologic and non-gynecologic diseases.

DESIGN AND METHODS: Sera from 176 patients with various diseases were collected, and CA125 and HE4 levels were compared. ROC curves were constructed to estimate the diagnostic performance.

RESULTS: Levels of both markers were elevated in ovarian cancer. CA125 was also high in benign gynecologic diseases, but HE4 was not. CA125 levels of pregnant women were higher than those of control group, and HE4 was increased in chronic renal diseases. The sensitivity for discriminating ovarian cancer from healthy or benign conditions was 44.8% for HE4 and 55.2% for CA125 at 95% specificity. The ROC-AUC values for HE4 and CA125 were 0.85 and 0.87 respectively.

CONCLUSIONS: HE4 demonstrated comparable diagnostic performances to CA125, though each marker had its own strengths and weaknesses. Combining CA125 and HE4 might be more advantageous than either one alone.
Full Text
http://www.sciencedirect.com/science/article/pii/S000991201100316X
DOI
10.1016/j.clinbiochem.2011.04.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Park, Yong Jung(박용정) ORCID logo https://orcid.org/0000-0001-5668-4120
Lee, Jong Han(이종한)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93412
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