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Enhanced cellular responses of vascular endothelial cells on poly-γ-glutamic acid/PU composite film treated with microwave-induced plasma at atmospheric pressure

Authors
 Bong Joo Park  ;  Byoung Ju Kwon  ;  Jae Kyeong Kang  ;  Mi Hee Lee  ;  Inho Han  ;  Jeong Koo Kim  ;  Jong-Chul Park 
Citation
 MACROMOLECULAR RESEARCH, Vol.19(6) : 537-541, 2011 
Journal Title
MACROMOLECULAR RESEARCH
ISSN
 1598-5032 
Issue Date
2011
Keywords
poly-γ-glutamic acid ; polyurethane ; human umbilical vein endothelial cells ; microwave-induced argon plasma
Abstract
Poly-γ-glutamic acid (γ-PGA), which is produced by microbial fermentation, is a biodegradable, hydrophilic and non-toxic biomaterial. γ-PGA has many carboxyl groups that makes it a polyanionic biopolymer with swelling ability, biocompatibility and anticoagulant activity. On the other hand, few studies have examined the effect of γ-PGA on the cellular activity of human umbilical vein endothelial cells (HUVECs). The present study evaluated the effects of γ-PGA and fabricated γ-PGA/PU composite films on the attachment and proliferation of HUVECs after treatment with microwave plasma at atmospheric pressure. The results confirmed that γ-PGA is capable of increasing the proliferation and differentiation of HUVECs to form capillary tubes with enhanced alignment and organization. Moreover, the microwave plasma modified γ-PGA/PU composite film was more hydrophilic and the surface roughness was enhanced. In addition, the attachment and proliferation of the HUVECs were increased by the plasma treatment. These results suggest that γ-PGA and surface modified γ-PGA/PU composite can be applied as bioactive and biocompatible materials in vascular tissue engineering but further testing of γ-PGA and γ-PGA/PU composite films will be needed to confirm the potential effects for use in vascular applications
Full Text
http://link.springer.com/article/10.1007%2Fs13233-011-0605-6#
DOI
10.1007/s13233-011-0605-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jae Kyeong(강재경)
Kwon, Byeong-Ju(권병주) ORCID logo https://orcid.org/0000-0001-9916-0546
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
Han, In Ho(한인호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93408
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