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Focal time-to-peak changes on perfusion MRI in children with Moyamoya disease: correlation with conventional angiography

Authors
 Hyun Seok Choi  ;  Dong-Seok Kim  ;  Kyu-Won Shim  ;  Jinna Kim  ;  Eun Soo Kim  ;  Seung-Koo Lee 
Citation
 ACTA RADIOLOGICA, Vol.52(6) : 675-679, 2011 
Journal Title
ACTA RADIOLOGICA
ISSN
 0284-1851 
Issue Date
2011
MeSH
Adolescent ; CerebralAngiography/methods* ; Child ; Child, Preschool ; DiseaseProgression ; Female ; Humans ; Magnetic ResonanceAngiography/methods* ; Male ; MoyamoyaDisease/diagnosis* ; Retrospective Studies ; Sensitivity and Specificity
Keywords
Moyamoya disease ; perfusion MRI ; time-to-peak map
Abstract
BACKGROUND: Moyamoya disease is a chronic progressive steno-occlusion of the distal internal carotid arteries with unknown etiology. As the classical presentation of childhood Moyamoya disease is ischemic stroke, cerebral hemodynamic evaluation is important for patient selection for surgery to prevent recurrent ischemic attacks. Perfusion MR imaging has been applied to evaluate cerebral hemodynamics.

PURPOSE: To correlate the 'basal time-to-peak preservation sign', 'auto-synangiosis sign', and 'posterior involvement sign' on time-to-peak map of perfusion MRI with catheter angiography.

MATERIAL AND METHODS: Thirty-four children (6.91 ± 3.08 years) with Moyamoya disease who underwent both perfusion-weighted MRI and catheter angiography were enrolled in this study. Given catheter angiography as a reference standard, basal time-to-peak preservation sign, auto-synangiosis sign, and posterior involvement sign were evaluated on time-to-peak maps.

RESULTS: The basal time-to-peak preservation sign was accurate for the diagnosis of childhood Moyamoya disease; both sensitivity and specificity were 100%. The auto-synangiosis sign showed lower sensitivity (65%), however, with an acceptable specificity (98%). The posterior involvement sign showed lower sensitivity (61%) but had an acceptable specificity (96%).

CONCLUSION: The basal time-to-peak preservation sign may be a universal finding in childhood Moyamoya disease. The auto-synangiosis and posterior involvement sign may be useful in determining transdural collateral status and posterior circulation involvement in childhood Moyamoya disease.
Full Text
http://acr.sagepub.com/content/52/6/675.long
DOI
10.1258/ar.2011.100495
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Seok(김동석)
Kim, Eun Soo(김은수)
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
Shim, Kyu Won(심규원) ORCID logo https://orcid.org/0000-0002-9441-7354
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Choi, Hyun Seok(최현석) ORCID logo https://orcid.org/0000-0003-4999-8513
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93367
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