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Predictive factors for indeterminate result on the QuantiFERON test in an intermediate tuberculosis-burden country

Authors
 Su Jin Jeong  ;  Sang Hoon Han  ;  Chang Oh Kim  ;  Ji-hyeon Baek  ;  Sung Joon Jin  ;  Nam Su Ku  ;  Jun Yong Choi  ;  Young Goo Song  ;  Hyon-Suk Kim  ;  June Myung Kim 
Citation
 JOURNAL OF INFECTION, Vol.62(5) : 347-354, 2011 
Journal Title
JOURNAL OF INFECTION
ISSN
 0163-4453 
Issue Date
2011
MeSH
Adult ; Aged ; Case-Control Studies ; Clinical Laboratory Techniques/methods* ; Female ; Humans ; Immunoassay/methods ; Immunocompromised Host ; Interferon-gamma/secretion* ; Leukocytes, Mononuclear/immunology* ; Lymphocyte Count ; Male ; Middle Aged ; Reagent Kits, Diagnostic ; Republic of Korea ; Sensitivity and Specificity ; Tuberculosis/diagnosis*
Keywords
Interferon-gamma release assays ; QuantiFERON-TB Gold In-Tube test ; Indeterminate results ; Predictive factors
Abstract
OBJECTIVES: The QuantiFERON-TB Gold In-Tube (QFT-G IT) test is based on the cellular immune response, and this assay can result in indeterminate results for the diagnosis of tuberculosis. The occurrence of indeterminate results may decrease the clinical usefulness of this test. Therefore, we investigated possible predictive factors that can influence the occurrence of indeterminate results from the QFT-G IT test.

METHODS: We conducted a case-control study with 162 case patients who had indeterminate results from a QFT-G IT test at a tertiary hospital in South Korea, from September 2006 to September 2009.

RESULTS: Of the 1276 patients, 162 (12.7%) cases that underwent QFT-G IT testing were reported as indeterminate results. Severe lymphopenia (odds ratio [OR] = 8.839; p < 0.001), chronic renal disease (OR = 2.838; p = 0.007), autoimmune disease (OR = 2.527; p = 0.017) and chronic lung disease (OR = 3.169; p = 0.007) were independent predictive factors for indeterminate results from a QFT-G IT test.

CONCLUSION: The patients with lower lymphocyte counts or immunosuppressive conditions showed a higher probability of indeterminate results from the QFT-G IT test. Careful attention to the pre-analytical conditions may be able to minimize this proportion.
Full Text
http://www.sciencedirect.com/science/article/pii/S0163445311000697
DOI
10.1016/j.jinf.2011.03.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Baek, Ji Hyeon(백지현)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Jin, Sung Joon(진성준)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93336
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