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Predictive factors for indeterminate result on the QuantiFERON test in an intermediate tuberculosis-burden country

Authors
 Su Jin Jeong ; Sang Hoon Han ; June Myung Kim ; Hyon-Suk Kim ; Young Goo Song ; Jun Yong Choi ; Nam Su Ku ; Sung Joon Jin ; Ji-hyeon Baek ; Chang Oh Kim 
Citation
 Journal of Infection, Vol.62(5) : 347~354, 2011 
Journal Title
 Journal of Infection 
ISSN
 0163-4453 
Issue Date
2011
Abstract
OBJECTIVES: The QuantiFERON-TB Gold In-Tube (QFT-G IT) test is based on the cellular immune response, and this assay can result in indeterminate results for the diagnosis of tuberculosis. The occurrence of indeterminate results may decrease the clinical usefulness of this test. Therefore, we investigated possible predictive factors that can influence the occurrence of indeterminate results from the QFT-G IT test. METHODS: We conducted a case-control study with 162 case patients who had indeterminate results from a QFT-G IT test at a tertiary hospital in South Korea, from September 2006 to September 2009. RESULTS: Of the 1276 patients, 162 (12.7%) cases that underwent QFT-G IT testing were reported as indeterminate results. Severe lymphopenia (odds ratio [OR] = 8.839; p < 0.001), chronic renal disease (OR = 2.838; p = 0.007), autoimmune disease (OR = 2.527; p = 0.017) and chronic lung disease (OR = 3.169; p = 0.007) were independent predictive factors for indeterminate results from a QFT-G IT test. CONCLUSION: The patients with lower lymphocyte counts or immunosuppressive conditions showed a higher probability of indeterminate results from the QFT-G IT test. Careful attention to the pre-analytical conditions may be able to minimize this proportion.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93336
DOI
10.1016/j.jinf.2011.03.004
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0163445311000697
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