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Inadequate cytology in thyroid nodules: should we repeat aspiration or follow-up?

Authors
 Jung Hyun Yoon  ;  Hee Jung Moon  ;  Eun-Kyung Kim  ;  Jin Young Kwak 
Citation
 ANNALS OF SURGICAL ONCOLOGY, Vol.18(5) : 1282-1289, 2011 
Journal Title
ANNALS OF SURGICAL ONCOLOGY
ISSN
 1068-9265 
Issue Date
2011
MeSH
Biopsy, Fine-Needle* ; Cytodiagnosis ; Cytological Techniques ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Thyroid Gland/pathology* ; Thyroid Neoplasms/diagnosis* ; Thyroid Neoplasms/surgery ; Thyroid Nodule/diagnosis* ; Thyroid Nodule/surgery ; Ultrasonography
Keywords
Nodule ; Papillary Thyroid Carcinoma ; Thyroid Nodule ; Malignant Nodule ; Malignancy Rate
Abstract
BACKGROUND: To evaluate how to correctly manage thyroid nodules showing inadequate cytology after ultrasound (US)-guided fine-needle aspiration biopsy (US-FNAB).

MATERIALS AND METHODS: A total of 393 thyroid nodules with inadequate cytology in 351 patients (M:F = 40:311, mean age: 49.3 years) with surgery or follow-up US-FNAB for at least 1 year were included in this study. Among them, 293 (74.6%) were benign and 100 (25.4%) were malignant on final reference results. Clinical characteristics and US features were reviewed and compared.

RESULTS: Malignancy rates (39.5%) of nodules having suspicious US feature were significantly higher than those (10.9%) of nodules without any suspicious US feature (P < .001). Malignancy rates of solid nodules, mainly solid nodules, and mainly cystic nodules were 29.2, 16.7, and 9.5%, respectively, with significant differences (P = .016). Malignancy rates of nodules assessed as suspicious malignant to probably benign in composition are: 39.1-12.8% (P < .001) in solid nodules, 42.1-9.2% (P = .001) in mainly solid nodules, and 50.0-5.3% (P = .04) in mainly cystic nodules.

CONCLUSIONS: In nodules with inadequate cytology, follow-up US can be considered over repeat aspiration if there are no suspicious US features present, especially in mainly cystic nodules.
Full Text
http://link.springer.com/article/10.1245%2Fs10434-011-1605-7
DOI
10.1245/s10434-011-1605-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93040
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