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Rapid analgesic onset of intra-articular hyaluronic acid with ketorolac in osteoarthritis of the knee

Authors
 Sang Chul Lee  ;  Dong-Wook Rha  ;  Won Hyuk Chang 
Citation
 JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION, Vol.24(1) : 31-38, 2011 
Journal Title
JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION
ISSN
 1053-8127 
Issue Date
2011
MeSH
Aged ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use* ; Arthralgia/drug therapy ; Arthralgia/etiology ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Humans ; Hyaluronic Acid/administration & dosage ; Hyaluronic Acid/adverse effects ; Hyaluronic Acid/therapeutic use* ; Injections, Intra-Articular ; Ketorolac/administration & dosage ; Ketorolac/adverse effects ; Ketorolac/therapeutic use* ; Male ; Middle Aged ; Osteoarthritis, Knee/complications ; Osteoarthritis, Knee/drug therapy* ; Pain Measurement ; Prospective Studies ; Single-Blind Method ; Treatment Outcome
Abstract
OBJECTIVE: The purpose of this study was to evaluate the efficacy of intra-articular ketorolac to improve intra-articular hyaluronic acid (HA) therapy in knee osteoarthritis with respect to the initiation of pain relief.

METHODS: This study was designed as a single-blind study with a blinded observer and a 3-month follow-up. Forty-three patients with knee osteoarthritis were randomized to the ketorolac group (n=21) or the HA group (n=22). Ketorolac group members were given three weekly intra-articular injections of HA with ketorolac and then two weekly intra-articular injections of HA; and HA group members were given five weekly intra-articular HA injections. Visual analog scale (VAS), pain rating score (PRS) and adverse events were assessed at baseline and at 1st, 3rd, 5th, and 16th week after treatment commencement.

RESULTS: Significant improvement regarding pain assessment tools was observed in the ketorolac group by the addition of ketorolac to HA as compared with the HA group within 16 weeks of follow-up (p < 0.05). In the ketorolac group, 5 of the 21 subjects developed focal post-injection knee pain for about 8 hours after injection.

CONCLUSION: Intra-articular HA with ketorolac showed more rapid analgesic onset than intra-articular HA alone and did not induce any serious complications.
Full Text
http://iospress.metapress.com/content/51h04267t0286376/?genre=article&issn=1053-8127&volume=24&issue=1&spage=31
DOI
10.3233/BMR20110272
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Rha, Dong Wook(나동욱) ORCID logo https://orcid.org/0000-0002-7153-4937
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93030
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