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Rapid analgesic onset of intra-articular hyaluronic acid with ketorolac in osteoarthritis of the knee
DC Field | Value | Language |
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dc.contributor.author | 나동욱 | - |
dc.date.accessioned | 2014-12-20T16:36:17Z | - |
dc.date.available | 2014-12-20T16:36:17Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1053-8127 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93030 | - |
dc.description.abstract | OBJECTIVE: The purpose of this study was to evaluate the efficacy of intra-articular ketorolac to improve intra-articular hyaluronic acid (HA) therapy in knee osteoarthritis with respect to the initiation of pain relief. METHODS: This study was designed as a single-blind study with a blinded observer and a 3-month follow-up. Forty-three patients with knee osteoarthritis were randomized to the ketorolac group (n=21) or the HA group (n=22). Ketorolac group members were given three weekly intra-articular injections of HA with ketorolac and then two weekly intra-articular injections of HA; and HA group members were given five weekly intra-articular HA injections. Visual analog scale (VAS), pain rating score (PRS) and adverse events were assessed at baseline and at 1st, 3rd, 5th, and 16th week after treatment commencement. RESULTS: Significant improvement regarding pain assessment tools was observed in the ketorolac group by the addition of ketorolac to HA as compared with the HA group within 16 weeks of follow-up (p < 0.05). In the ketorolac group, 5 of the 21 subjects developed focal post-injection knee pain for about 8 hours after injection. CONCLUSION: Intra-articular HA with ketorolac showed more rapid analgesic onset than intra-articular HA alone and did not induce any serious complications. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 31~38 | - |
dc.relation.isPartOf | JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal/administration & dosage | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal/adverse effects | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal/therapeutic use* | - |
dc.subject.MESH | Arthralgia/drug therapy | - |
dc.subject.MESH | Arthralgia/etiology | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyaluronic Acid/administration & dosage | - |
dc.subject.MESH | Hyaluronic Acid/adverse effects | - |
dc.subject.MESH | Hyaluronic Acid/therapeutic use* | - |
dc.subject.MESH | Injections, Intra-Articular | - |
dc.subject.MESH | Ketorolac/administration & dosage | - |
dc.subject.MESH | Ketorolac/adverse effects | - |
dc.subject.MESH | Ketorolac/therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Osteoarthritis, Knee/complications | - |
dc.subject.MESH | Osteoarthritis, Knee/drug therapy* | - |
dc.subject.MESH | Pain Measurement | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Single-Blind Method | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Rapid analgesic onset of intra-articular hyaluronic acid with ketorolac in osteoarthritis of the knee | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Rehabilitation Medicine (재활의학) | - |
dc.contributor.googleauthor | Sang Chul Lee | - |
dc.contributor.googleauthor | Dong-Wook Rha | - |
dc.contributor.googleauthor | Won Hyuk Chang | - |
dc.identifier.doi | 10.3233/BMR20110272 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01230 | - |
dc.relation.journalcode | J01253 | - |
dc.identifier.eissn | 1878-6324 | - |
dc.identifier.pmid | 21248398 | - |
dc.identifier.url | http://iospress.metapress.com/content/51h04267t0286376/?genre=article&issn=1053-8127&volume=24&issue=1&spage=31 | - |
dc.contributor.alternativeName | Rha, Dong Wook | - |
dc.contributor.affiliatedAuthor | Rha, Dong Wook | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 24 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 31 | - |
dc.citation.endPage | 38 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION, Vol.24(1) : 31-38, 2011 | - |
dc.identifier.rimsid | 27983 | - |
dc.type.rims | ART | - |
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