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Comparisons of nerve fiber layer thickness measurements between Stratus, Cirrus, and RTVue OCTs in healthy and glaucomatous eyes.

 Eun Suk Lee  ;  Sung Yong Kang  ;  Chan Yun Kim  ;  Gong Je Seong  ;  Na Rae Kim  ;  Ji Hyun Kim  ;  Eun Hee Choi 
 Optometry and Vision Science, Vol.88(6) : 751-758, 2011 
Journal Title
 Optometry and Vision Science 
Issue Date
PURPOSE: To compare retinal nerve fiber layer (RNFL) measurements obtained by two spectral-domain optical coherence tomographies (SD OCTs; Cirrus-HD OCT and RTVue) and a time domain OCT (TD OCT; Stratus OCT). The diagnostic ability of the three instruments for glaucoma has also been compared. METHODS: One hundred eight open-angle glaucoma patients and 46 normal controls were enrolled. Three OCT scans were repeated to obtain peripapillary RNFL thickness measurements from all participants on the same day. The relationships between RNFL measurements from three OCTs were evaluated with regression analyses. RESULTS: The thickest RNFL measurements were generally obtained with the RTVue, followed by the Stratus, and finally by the Cirrus OCT (mixed model, p < 0.05). However, the tendency was reversed or no longer present in severe glaucomatous eyes and nasal quadrant maps. Regression analysis between the TD OCT and the two SD OCTs revealed a quadratic relation (linear vs. non-linear, Akaike information criterion, all p < 0.05), whereby RNFL measurements of the TD OCT became exponentially thinner than those by the SD OCTs in thin RNFL thicknesses. Comparing the two SD OCTs, RTVue measured thicker values consistently regardless of the RNFL thickness (pairwise comparisons, p < 0.05). There were no significant differences in the diagnostic ability of all three instruments in average and each quadrants of RNFL thickness (p > 0.05). CONCLUSIONS: Direct comparisons of RNFL thickness measurements among OCT instruments may be misleading as there are considerable differences among devices. The measurement differences between SD OCT and TD OCT differed according to the RNFL thickness and also possibly to severity of the glaucoma. The diagnostic ability of each instrument for glaucoma detection was not significantly different.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biostatistics (의학통계학과)
Yonsei Authors
강성용(Kang, Sung Yong) ; 김나래(Kim, Na Rae) ; 김지현(Kim, Ji Hyun) ; 김찬윤(Kim, Chan Yun) ; 성공제(Seong, Gong Je) ; 이은석(Lee, Eun Suk) ; 최은희(Choi, Eun Hee)
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