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Comparisons of nerve fiber layer thickness measurements between Stratus, Cirrus, and RTVue OCTs in healthy and glaucomatous eyes.

Authors
 Eun Suk Lee  ;  Sung Yong Kang  ;  Eun Hee Choi  ;  Ji Hyun Kim  ;  Na Rae Kim  ;  Gong Je Seong  ;  Chan Yun Kim 
Citation
 OPTOMETRY AND VISION SCIENCE, Vol.88(6) : 751-758, 2011 
Journal Title
OPTOMETRY AND VISION SCIENCE
ISSN
 1040-5488 
Issue Date
2011
MeSH
Adult ; Aged ; Female ; Glaucoma, Open-Angle/diagnosis* ; Humans ; Male ; Middle Aged ; Nerve Fibers/pathology* ; Regression Analysis ; Retina/pathology* ; Tomography, Optical Coherence/methods* ; Tomography, Optical Coherence/standards
Abstract
PURPOSE: To compare retinal nerve fiber layer (RNFL) measurements obtained by two spectral-domain optical coherence tomographies (SD OCTs; Cirrus-HD OCT and RTVue) and a time domain OCT (TD OCT; Stratus OCT). The diagnostic ability of the three instruments for glaucoma has also been compared.

METHODS: One hundred eight open-angle glaucoma patients and 46 normal controls were enrolled. Three OCT scans were repeated to obtain peripapillary RNFL thickness measurements from all participants on the same day. The relationships between RNFL measurements from three OCTs were evaluated with regression analyses.

RESULTS: The thickest RNFL measurements were generally obtained with the RTVue, followed by the Stratus, and finally by the Cirrus OCT (mixed model, p < 0.05). However, the tendency was reversed or no longer present in severe glaucomatous eyes and nasal quadrant maps. Regression analysis between the TD OCT and the two SD OCTs revealed a quadratic relation (linear vs. non-linear, Akaike information criterion, all p < 0.05), whereby RNFL measurements of the TD OCT became exponentially thinner than those by the SD OCTs in thin RNFL thicknesses. Comparing the two SD OCTs, RTVue measured thicker values consistently regardless of the RNFL thickness (pairwise comparisons, p < 0.05). There were no significant differences in the diagnostic ability of all three instruments in average and each quadrants of RNFL thickness (p > 0.05).

CONCLUSIONS: Direct comparisons of RNFL thickness measurements among OCT instruments may be misleading as there are considerable differences among devices. The measurement differences between SD OCT and TD OCT differed according to the RNFL thickness and also possibly to severity of the glaucoma. The diagnostic ability of each instrument for glaucoma detection was not significantly different.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006324-201106000-00014&LSLINK=80&D=ovft
DOI
10.1097/OPX.0b013e318215cc40
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sung Yong(강성용)
Kim, Na Rae(김나래)
Kim, Ji Hyun(김지현)
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Eun Suk(이은석)
Choi, Eun Hee(최은희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93017
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