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Regulation of DREAM Expression by Group I mGluR

Authors
 Jinu Lee  ;  Insook Kim  ;  So Ra Oh  ;  Suk Jin Ko  ;  Mi Kyung Lim  ;  , Dong Goo Kim  ;  Chul Hoon Kim 
Citation
 Korean Journal of Physiology & Pharmacology, Vol.15(2) : 95-100, 2011 
Journal Title
 Korean Journal of Physiology & Pharmacology 
ISSN
 1226-4512 
Issue Date
2011
Abstract
DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92849
Files in This Item:
T201100889.pdf Download
DOI
10.4196/kjpp.2011.15.2.95
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실)
Yonsei Authors
김동구(Kim, Dong Goo)
김철훈(Kim, Chul Hoon)
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