Cited 3 times in
Regulation of DREAM Expression by Group I mGluR
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동구 | - |
dc.contributor.author | 김철훈 | - |
dc.date.accessioned | 2014-12-20T16:30:32Z | - |
dc.date.available | 2014-12-20T16:30:32Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92849 | - |
dc.description.abstract | DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 95~100 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Regulation of DREAM Expression by Group I mGluR | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Jinu Lee | - |
dc.contributor.googleauthor | Insook Kim | - |
dc.contributor.googleauthor | So Ra Oh | - |
dc.contributor.googleauthor | Suk Jin Ko | - |
dc.contributor.googleauthor | Mi Kyung Lim | - |
dc.contributor.googleauthor | , Dong Goo Kim | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.identifier.doi | 10.4196/kjpp.2011.15.2.95 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00396 | - |
dc.contributor.localId | A01057 | - |
dc.relation.journalcode | J02104 | - |
dc.identifier.eissn | 2093-3827 | - |
dc.identifier.pmid | 21660149 | - |
dc.subject.keyword | Calcium | - |
dc.subject.keyword | DREAM | - |
dc.subject.keyword | Group I mGluR | - |
dc.subject.keyword | Pain | - |
dc.subject.keyword | mGluR1 | - |
dc.subject.keyword | mGluR5 | - |
dc.contributor.alternativeName | Kim, Dong Goo | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Dong Goo | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 15 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 95 | - |
dc.citation.endPage | 100 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, Vol.15(2) : 95-100, 2011 | - |
dc.identifier.rimsid | 28794 | - |
dc.type.rims | ART | - |
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