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Gene expression signature-based prognostic risk score in gastric cancer

Authors
 Jae Yong Cho  ;  Jae Yun Lim  ;  Jae Ho Cheong 
Citation
 Clinical Cancer Research, Vol.17(7) : 1850-1857, 2011 
Journal Title
 Clinical Cancer Research 
ISSN
 1078-0432 
Issue Date
2011
Abstract
PURPOSE: Despite continual efforts to develop a prognostic model of gastric cancer by using clinical and pathologic parameters, a clinical test that can discriminate patients with good outcomes from those with poor outcomes after gastric cancer surgery has not been established. We aim to develop practical biomarker-based risk score that can predict relapse of gastric cancer after surgical treatment. EXPERIMENTAL DESIGN: Microarray technologies were used to generate and analyze gene expression profiling data from 65 gastric cancer patients to identify biomarker genes associated with relapse. The association of expression patterns of identified genes with relapse and overall survival was validated in independent gastric cancer patients. RESULTS: We uncovered two subgroups of gastric cancer that were strongly associated with the prognosis. For the easy translation of our findings into practice, we developed a scoring system based on the expression of six genes that predicted the likelihood of relapse after curative resection. In multivariate analysis, the risk score was an independent predictor of relapse in a cohort of 96 patients. We were able to validate the robustness of the six-gene signature in an additional independent cohort. CONCLUSIONS: The risk score derived from the six-gene set successfully prognosticated the relapse of gastric cancer patients after gastrectomy.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92845
DOI
10.1158/1078-0432.CCR-10-2180
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
김호근(Kim, Ho Keun)
노성훈(Noh, Sung Hoon)
박영년(Park, Young Nyun)
임재윤(Lim, Jae Yun)
정재호(Cheong, Jae Ho)
조재용(Cho, Jae Yong)
홍순원(Hong, Soon Won)
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