404 762

Cited 271 times in

Gene expression signature-based prognostic risk score in gastric cancer

DC Field Value Language
dc.contributor.author김호근-
dc.contributor.author노성훈-
dc.contributor.author박영년-
dc.contributor.author임재윤-
dc.contributor.author정재호-
dc.contributor.author조재용-
dc.contributor.author홍순원-
dc.date.accessioned2014-12-20T16:30:25Z-
dc.date.available2014-12-20T16:30:25Z-
dc.date.issued2011-
dc.identifier.issn1078-0432-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92845-
dc.description.abstractPURPOSE: Despite continual efforts to develop a prognostic model of gastric cancer by using clinical and pathologic parameters, a clinical test that can discriminate patients with good outcomes from those with poor outcomes after gastric cancer surgery has not been established. We aim to develop practical biomarker-based risk score that can predict relapse of gastric cancer after surgical treatment. EXPERIMENTAL DESIGN: Microarray technologies were used to generate and analyze gene expression profiling data from 65 gastric cancer patients to identify biomarker genes associated with relapse. The association of expression patterns of identified genes with relapse and overall survival was validated in independent gastric cancer patients. RESULTS: We uncovered two subgroups of gastric cancer that were strongly associated with the prognosis. For the easy translation of our findings into practice, we developed a scoring system based on the expression of six genes that predicted the likelihood of relapse after curative resection. In multivariate analysis, the risk score was an independent predictor of relapse in a cohort of 96 patients. We were able to validate the robustness of the six-gene signature in an additional independent cohort. CONCLUSIONS: The risk score derived from the six-gene set successfully prognosticated the relapse of gastric cancer patients after gastrectomy.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfCLINICAL CANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/diagnosis*-
dc.subject.MESHAdenocarcinoma/genetics-
dc.subject.MESHAdenocarcinoma/metabolism-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiomarkers, Tumor/metabolism*-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHGastrointestinal Stromal Tumors/diagnosis-
dc.subject.MESHGastrointestinal Stromal Tumors/genetics-
dc.subject.MESHGastrointestinal Stromal Tumors/metabolism-
dc.subject.MESHGene Expression Profiling*-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNeoplasm Recurrence, Local-
dc.subject.MESHOdds Ratio-
dc.subject.MESHOligonucleotide Array Sequence Analysis-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHROC Curve-
dc.subject.MESHStomach Neoplasms/diagnosis*-
dc.subject.MESHStomach Neoplasms/genetics-
dc.subject.MESHStomach Neoplasms/metabolism-
dc.titleGene expression signature-based prognostic risk score in gastric cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJae Yong Cho-
dc.contributor.googleauthorJae Yun Lim-
dc.contributor.googleauthorJae Ho Cheong-
dc.identifier.doi10.1158/1078-0432.CCR-10-2180-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01183-
dc.contributor.localIdA01281-
dc.contributor.localIdA01563-
dc.contributor.localIdA03398-
dc.contributor.localIdA03717-
dc.contributor.localIdA03899-
dc.contributor.localIdA04411-
dc.relation.journalcodeJ00564-
dc.identifier.pmid21447720-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNameLim, Jae Yun-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.alternativeNameCho, Jae Yong-
dc.contributor.alternativeNameHong, Soon Won-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorLim, Jae Yun-
dc.contributor.affiliatedAuthorCheong, Jae Ho-
dc.contributor.affiliatedAuthorCho, Jae Yong-
dc.contributor.affiliatedAuthorHong, Soon Won-
dc.rights.accessRightsfree-
dc.citation.volume17-
dc.citation.number7-
dc.citation.startPage1850-
dc.citation.endPage1857-
dc.identifier.bibliographicCitationCLINICAL CANCER RESEARCH, Vol.17(7) : 1850-1857, 2011-
dc.identifier.rimsid28792-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.