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Interval growth of probably benign breast lesions on follow-up ultrasound: how can these be managed?

 Hee Jung Moon  ;  Eun-Kyung Kim  ;  Jin Young Kwak  ;  Jung Hyun Yoon  ;  Min Jung Kim 
 EUROPEAN RADIOLOGY, Vol.21(5) : 908-918, 2011 
Journal Title
Issue Date
Adult ; Aged ; Biopsy ; Breast/pathology* ; Breast Neoplasms/diagnosis* ; Breast Neoplasms/diagnostic imaging* ; Diagnostic Imaging/methods ; Female ; Humans ; Medical Oncology/methods ; Middle Aged ; Predictive Value of Tests ; ROC Curve ; Retrospective Studies ; Ultrasonography/methods* ; Ultrasonography, Mammary/methods*
Breast ; Neoplasm ; Indeterminate mass ; Ultrasound surveillance ; Biopsy
OBJECTIVES: To investigate the malignancy rate in probably benign lesions with interval growth on follow-up ultrasound (US) and the cut-off values for predicting malignancy. METHODS: By retrospective reviewing 19,435 US examinations assessed as probably benign lesions, a total of 214 lesions with interval growth in 199 patients were included. The increased volume (%V),%V per month, the most increased diameter (D), and D per month were compared between malignant and benign lesions. Malignancy rates were compared between lesions with or without newly developed suspicious malignant features. RESULTS: Twenty-two (10.3%) malignancies showed significant increase in%V,%V per month, D, and D per month compared with 192 (89.7%) benign lesions (p = 0.0083, <0.0001, <0.0001, and <0.0001, respectively). Fifteen (38.5%) of 39 lesions where suspicious features developed proved malignant, whereas 7 (4%) out of 175 without were malignant (p = 0.0011). In nodules without suspicious features, 24.2% of%V per month and 1.9 mm of D per month showed high sensitivity (85.7% and 71.4%) and specificity (67.8% and 97.6%) for predicting malignancy. CONCLUSIONS: Probably benign lesions with interval growth should undergo prompt biopsy because of the 10.3% malignancy rate. In lesions where suspicious features developed, the malignancy rate increased to 38.5%.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
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