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Comparison of outcomes among secondary covered metallic, uncovered metallic, and plastic biliary stents in treating occluded primary metallic stents in malignant distal biliary obstruction

Authors
 Jae Hee Cho  ;  Tae Joo Jeon  ;  Seungmin Bang  ;  Si Young Song  ;  Jae Bock Chung  ;  Seung Woo Park  ;  Yoon Jae Kim  ;  Hee Man Kim  ;  Jeong Youp Park 
Citation
 Surgical Endoscopy , Vol.25(2) : 475-482, 2011 
Journal Title
 Surgical Endoscopy  
ISSN
 0930-2794 
Issue Date
2011
Abstract
BACKGROUND: The self-expandable metallic stent (SEMS) has been widely used for unresectable malignant biliary obstruction but eventually becomes occluded by tumor ingrowth/overgrowth and sludge. Therefore, we aimed to determine the therapeutic effectiveness of secondary stents and to find differences according to various combinations of the first and second stents for the management of occluded SEMSs in patients with malignant distal biliary obstruction. METHODS: Between 1999 and November 2008, 77 patients with malignant biliary obstruction underwent secondary biliary stent placement as "stent-in-stent" at three university hospitals in Korea (40 covered, 26 uncovered, and 11 plastic stents). The membrane of the covered SEMS was regarded as the barrier against tumor ingrowth. We categorized the patients into three groups based on whether the covered SEMS was either the first or the second stent: membrane-SEMS (18 covered-covered; 9 covered-uncovered; 22 uncovered-covered SEMS), bare-SEMS (17 uncovered-uncovered SEMS), and plastic stent (3 covered-plastic; 8 uncovered-plastic). RESULTS: The median patency of second stents was 138, 109, and 88 days (covered, uncovered, and plastic stents). The second covered SEMSs had a significantly longer patency than plastic stents (p=0.047). In a multivariate analysis including membrane-SEMS, bare-SEMS, and plastic stent groups, the bare-SEMS had a worse cumulative stent patency (HR=2.04, CI=1.08-3.86) and survival time (HR=2.37, CI=1.25-4.49) than the membrane-SEMS. Patients with ampulla of Vater cancer had better stent patency (HR=0.27, CI=0.08-0.98) and survival (HR=0.17, CI=0.04-0.77) than those with other pancreatobiliary malignancies. In addition, antitumor treatment prolonged survival time (HR=0.50, CI=0.26-0.99). CONCLUSIONS: The placement of additional biliary stents using the "stent-in-stent" method is an effective treatment for an occluded metallic primary stent. In addition, double biliary SEMS placement using at least one covered SEMS (in the primary and/or secondary procedure) might provide longer cumulative stent patency and survival than using uncovered SEMSs in both procedures.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92725
DOI
10.1007/s00464-010-1196-6
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김윤재(Kim, Yoon Jae) ; 김희만(Kim, Hee Man) ; 박승우(Park, Seung Woo) ; 박정엽(Park, Jeong Youp) ; 방승민(Bang, Seung Min) ; 송시영(Song, Si Young) ; 전태주(Jeon, Tae Joo) ; 정재복(Chung, Jae Bock) ; 조재희(Cho, Jae Hee)
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Full Text
http://link.springer.com/article/10.1007%2Fs00464-010-1196-6
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