294 204

Cited 31 times in

Laminin-332-rich tumor microenvironment for tumor invasion in the interface zone of breast cancer.

Authors
 Baek Gil Kim  ;  Hee Jung An  ;  Nam Hoon Cho  ;  Haengran Park  ;  Ming-Qing Gao  ;  Yoon Pyo Choi  ;  Suki Kang 
Citation
 American Journal of Pathology, Vol.178(1) : 373-381, 2011 
Journal Title
 American Journal of Pathology 
ISSN
 0002-9440 
Issue Date
2011
Abstract
Dense fibrosis, which is caused by desmoplastic reaction, is usually found in invasive ductal carcinoma and may represent the alteration of the tumor microenvironment preceding tumor invasion. Thus, the dense fibrotic zone around invasive ductal carcinoma can be considered to be the actual tissue site of tumor microenvironment, where the precedent alterations for tumor invasion occur. To characterize the dense fibrotic zone, we classified invasive ductal carcinoma tissue into a tumor zone, a normal zone, and the novel interface zone (IZ), which shows dense fibrosis. The postulated IZ is a 5-mm-wide belt that circles the tumor margin and overlaps with normal tissue. Of the extracellular matrix components, laminin-332 was specifically overexpressed in the IZ. Events that appear to be similar to the epithelial-mesenchymal transition, a novel source of myofibroblast formation from epithelial cells, were observed in the IZ, according to the following characteristics: overexpression of matrix metalloproteinase 3, membrane type 1-matrix metalloproteinase, snail, and zinc finger E-box-binding homeobox 1, and the gain of N-cadherin expression, as well as the down-regulation of miR200c. The myofibroblasts isolated from the IZ, which were designated interface zone-fibroblast, displayed laminin-332 and membrane type 1-matrix metalloproteinase overexpression, in contrast with both cancer-associated fibroblasts and normal breast fibroblasts. Taken together, our results suggest that the IZ, which shows dense fibrosis, may provide a specialized microenvironment for guiding tumor invasion: the fibrosis caused by laminin-332 overexpressing myofibroblast formation (interface zone-fibroblast) via epithelial-mesenchymal transition.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92602
DOI
10.1016/j.ajpath.2010.11.028
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Life Science (의생명과학부)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
강숙희(Kang, Suki) ; 고명청(Gao, Ming Qing) ; 김백길(Kim, Baek Gil) ; 박행란(Park, Haeng Ran) ; 조남훈(Cho, Nam Hoon) ; 최윤표(Choi, Yoon Pyo)
사서에게 알리기
  feedback
Files in This Item:
T201100238.pdf Download
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse