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Neuroanatomical correlates of trait anhedonia in patients with schizophrenia: a voxel-based morphometric study

 Jung Suk Lee  ;  Hae-Jeong Park  ;  Ji Won Chun  ;  Jeong-Ho Seok  ;  Il-Ho Park  ;  Bumhee Park  ;  Jae-Jin Kim 
 Neuroscience Letters, Vol.489(2) : 110-114, 2011 
Journal Title
 Neuroscience Letters 
Issue Date
The aim of this study was to characterize the association between trait anhedonia and regional gray matter volume in patients with schizophrenia. Forty-six patients with schizophrenia and 56 healthy controls underwent magnetic resonance imaging (MRI) to acquire high-resolution T1-weighted images. Trait anhedonia was measured using the Chapman Revised Physical Anhedonia Scale (PAS). Voxel-based morphometry was performed to investigate brain volume correlates of trait anhedonia. Several brain regions in the patient group, including the left precuneus and right posterior cingulate (PCC), were found to show significantly less correlation with PAS scores than those of the control group. Post-hoc analysis revealed that negative correlations between the regional gray matter volume and the PAS scores in the patient group were found at a trend level in the left precuneus and the right PCC. In conclusion, these findings suggest that trait anhedonia in patients with schizophrenia could possibly be associated with a volume deficit in brain regions related to default-mode, which reflects the impairment of self-referential processing and reward anticipation
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute of Behavioral Sciences in Medicine (의학행동과학연구소)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
Yonsei Authors
김재진(Kim, Jae Jin) ORCID logo https://orcid.org/0000-0002-1395-4562
박범희(Park, Bum Hee)
박일호(Park, Il Ho)
석정호(Seok, Jeong Ho) ORCID logo https://orcid.org/0000-0002-9402-7591
이정석(Lee, Jung Suk)
전지원(Chun, Ji Won)
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