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젖산 농도와 관류 비를 이용한 흰쥐에서의 출혈성 쇼크의 사망 예측 지표 개발

Authors
 최재림  ;  최준열  ;  이완형  ;  권민경  ;  박인철  ;  김덕원 
Citation
 Journal of the Korean Society of Emergency Medicine, Vol.23(1) : 41-49, 2012 
Journal Title
Journal of the Korean Society of Emergency Medicine(대한응급의학회지)
ISSN
 1226-4334 
Issue Date
2012
Keywords
Hemorrhagic shock ; Perfusion ; Lactate ; Mortality ; Rats
Abstract
Purpose: We proposed a new index for predicting death resulting from hemorrhagic shock, which was calculated by dividing measured lactate concentration by perfusion. Methods: Using 24 Sprague-Dawley (S-D) rats, we induced uncontrolled hemorrhage and then measured blood lactate concentration and perfusion in addition to vital signs such as heart rate, blood pressure, respiration rate and temperature. Perfusion and lactate concentration were measured by laser Doppler flowmetry and a lactate concentration meter, respectively. We collected the data for 15 min, which consisted of 3 intervals after homeostasis, and thus obtained a new index. Results: The proposed index revealed an earlier death prediction than lactate concentration alone with the same timing as perfusion. The new index showed generally better sensitivity, specificity and accuracy than lactate concentration and perfusion. Using a receiver operating characteristic curve method, the mortality prediction with the proposed index resulted in a sensitivity of 98.0%, specificity of 90.0%, and accuracy of 93.7%. The mortality prediction with the proposed index resulted in a sensitivity of 98.0%, specificity of 90.0% and accuracy of 93.7%. Conclusion: This index could provide physicians, in emergency situations, with early and accurate mortality predictions for cases of human hemorrhagic shock.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Min Kyung(권민경)
Kim, Deok Won(김덕원)
Park, In Cheol(박인철) ORCID logo https://orcid.org/0000-0001-7033-766X
Lee, Wan Hyung(이완형)
Choi, Jae Lim(최재림)
Choi, Joon Yul(최준열)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92307
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