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Retinal Vascular Caliber Changes on OCT after Intravitreal Bevacizumab Injection in Diabetic Macular Edema.

Other Titles
 당뇨황반부종에서 안내 베바시주맙 치료 후 빛간섭단층촬영을 이용한 망막 혈관 직경의 변화 
Authors
 김영준  ;  김형은  ;  송원경  ;  김성수 
Citation
 Journal of the Korean Ophthalmological Society (대한안과학회지), Vol.53(2) : 262-267, 2012 
Journal Title
 Journal of the Korean Ophthalmological Society  (대한안과학회지) 
ISSN
 0378-6471 
Issue Date
2012
Abstract
PURPOSE: To investigate retinal vascular caliber changes with Spectral Domain OCT after intravitreal bevacizumab injection in diabetic macular edema patients. METHODS: Thirty-four eyes of 29 diabetic macular edema patients who were intravitreously injected with bevacizumab (1.25 g/0.05 ml) were studied. Twenty-four fellow eyes of 24 patients with bevacizumab injection were also recruited as a control group. We measured retinal vascular caliber a distance of 0.5-1 disc sizes from the disc margin with Spectral Domain OCT at baseline and 1-month and 3-month follow-up visits. Central macular thicknesses were also measured. RESULTS: Over the 3 months of study, there was a significant reduction of arteriolar caliber compared to baseline (p = 0.024), There was significant reduction of venular caliber at 1 month (p = 0.001) and 3 months (p = 0.000) compared to baseline. Venular caliber reduction at the 3-month follow-up was significantly correlated with central macular thickness (R = 0.487, p = 0.003). CONCLUSIONS: Retinal venular caliber reduction was significant at 1- and 3-month follow-up, and arteriolar caliber reduction was significant at 3-month follow-up compared to baseline. After 3 months of treatment, venular caliber reduction was correlated with reduction of central macular thickness.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92280
Files in This Item:
T201203594.pdf Download
DOI
10.3341/jkos.2012.53.2.262
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실)
Yonsei Authors
김성수(Kim, Sung Soo)
김형은(Kim, Hyoung Eun)
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