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Effects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled Study.

Authors
 Byoung-Jin Park  ;  Yong-Jae Lee  ;  Hye-Ree Lee  ;  Dong-Hyuk Jung  ;  Ha-Young Na  ;  Hong-Bae Kim  ;  Jae-Yong Shim  ;  Hong-Bae Kim  ;  Jae-Yong Shim 
Citation
 Korean Journal of Family Medicine (가정의학회지), Vol.33(4) : 190-196, 2012 
Journal Title
 Korean Journal of Family Medicine  (가정의학회지) 
ISSN
 2005-6443 
Issue Date
2012
Abstract
BACKGROUND: This study investigated the effects of Korean red ginseng (KRG) supplementation on metabolic parameters, inflammatory markers, and arterial stiffness in subjects with metabolic syndrome. METHODS: We performed a randomized, double-blind, placebo-controlled, single-center study in 60 subjects who were not taking drugs that could affect metabolic and vascular functions. Subjects were randomized into either a KRG (4.5 g/d) group or a placebo group for a 12-week study. We collected anthropometric measurements, blood for laboratory testing, and brachial-ankle pulse wave velocity (baPWV) at the initial (week 0) and final (week 12) visits. RESULTS: A total of 48 subjects successfully completed the study protocol. Oral administration of KRG did not significantly affect blood pressure, oxidative or inflammatory markers, or baPWV. CONCLUSION: We found no evidence that KRG had an effect on blood pressure, lipid profile, oxidized low density lipoprotein, fasting blood glucose, or arterial stiffness in subjects with metabolic syndrome. These findings warrant subsequent longer-term prospective clinical investigations with a larger population. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT00976274
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92169
DOI
10.4082/kjfm.2012.33.4.190
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실)
Yonsei Authors
나하영(Na, Ha Young) ; 박병진(Park, Byoung Jin) ; 심재용(Shim, Jae Yong) ; 이용제(Lee, Yong Jae) ; 이혜리(Lee, Hye Ree) ; 정동혁(Jung, Dong Hyuk)
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