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Serum Ferritin Is Differentially Associated with Anti-oxidative Status and Insulin Resistance in Healthy Obese and Non-obese Women.

Authors
 Jee-Yon Lee  ;  Jae-Min Park  ;  Jung-Ah Hong  ;  Duk-Chul Lee  ;  Jee-Aee Im  ;  Ji-Won Lee 
Citation
 Korean Journal of Family Medicine (가정의학회지), Vol.33(4) : 205-210, 2012 
Journal Title
 Korean Journal of Family Medicine  (가정의학회지) 
ISSN
 2005-6443 
Issue Date
2012
Abstract
BACKGROUND: Ferritin is known to be associated with insulin resistance (IR) and oxidative stress; however, recent studies have shown that there is an association between ferritin and anti-oxidative status. To date, the biphasic response of ferritin to oxidative stress has not been fully evaluated. Thus, we investigated the association between ferritin and IR and anti-oxidative status in obese and non-obese women. METHODS: We evaluated the homeostasis model assessment of insulin resistance (HOMA-IR) and total anti-oxidant status (TAS) in a total of 111 healthy women between the ages of 32 and 68 years. RESULTS: In all of the study subjects, ferritin levels were positively correlated with age (r = 0.38, P < 0.001), body mass index (r = 0.24, P = 0.01), TAS (r = 0.38, P < 0.001) and HOMA-IR (r = 0.20, P = 0.04). In the subgroup analysis, ferritin levels were correlated with age (r = 0.39, P < 0.001) and TAS (r = 0.43, P < 0.001) in the non-obese group and with insulin (r = 0.50, P = 0.02) and HOMA-IR (r = 0.52, P = 0.01) levels in the obese group. On stepwise multiple linear regression analysis, ferritin was found to be independently associated with TAS (B = 177.16, P < 0.0001) in the non-obese group and independently associated with HOMA-IR (B = 30.36, P = 0.01) in the obese group. CONCLUSION: Our findings suggest ferritin is associated with IR in obese women and with anti-oxidative status in non-obese women. Further studies are warranted to elucidate the precise role of ferritin in obesity.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92168
DOI
10.4082/kjfm.2012.33.4.205
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실)
Yonsei Authors
이덕철(Lee, Duk Chul) ; 이지연(Lee, Jee Yon) ; 이지원(Lee, Ji Won) ; 홍정아(Hong, Jung Ah)
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