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Serum Ferritin Is Differentially Associated with Anti-oxidative Status and Insulin Resistance in Healthy Obese and Non-obese Women.

DC FieldValueLanguage
dc.contributor.author이덕철-
dc.contributor.author이지연-
dc.contributor.author이지원-
dc.contributor.author홍정아-
dc.contributor.author박재민-
dc.date.accessioned2014-12-19T17:50:48Z-
dc.date.available2014-12-19T17:50:48Z-
dc.date.issued2012-
dc.identifier.issn2005-6443-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92168-
dc.description.abstractBACKGROUND: Ferritin is known to be associated with insulin resistance (IR) and oxidative stress; however, recent studies have shown that there is an association between ferritin and anti-oxidative status. To date, the biphasic response of ferritin to oxidative stress has not been fully evaluated. Thus, we investigated the association between ferritin and IR and anti-oxidative status in obese and non-obese women. METHODS: We evaluated the homeostasis model assessment of insulin resistance (HOMA-IR) and total anti-oxidant status (TAS) in a total of 111 healthy women between the ages of 32 and 68 years. RESULTS: In all of the study subjects, ferritin levels were positively correlated with age (r = 0.38, P < 0.001), body mass index (r = 0.24, P = 0.01), TAS (r = 0.38, P < 0.001) and HOMA-IR (r = 0.20, P = 0.04). In the subgroup analysis, ferritin levels were correlated with age (r = 0.39, P < 0.001) and TAS (r = 0.43, P < 0.001) in the non-obese group and with insulin (r = 0.50, P = 0.02) and HOMA-IR (r = 0.52, P = 0.01) levels in the obese group. On stepwise multiple linear regression analysis, ferritin was found to be independently associated with TAS (B = 177.16, P < 0.0001) in the non-obese group and independently associated with HOMA-IR (B = 30.36, P = 0.01) in the obese group. CONCLUSION: Our findings suggest ferritin is associated with IR in obese women and with anti-oxidative status in non-obese women. Further studies are warranted to elucidate the precise role of ferritin in obesity.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfKorean Journal of Family Medicine-
dc.relation.isPartOf가정의학회지-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSerum Ferritin Is Differentially Associated with Anti-oxidative Status and Insulin Resistance in Healthy Obese and Non-obese Women.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학)-
dc.contributor.googleauthorJee-Yon Lee-
dc.contributor.googleauthorJae-Min Park-
dc.contributor.googleauthorJung-Ah Hong-
dc.contributor.googleauthorDuk-Chul Lee-
dc.contributor.googleauthorJee-Aee Im-
dc.contributor.googleauthorJi-Won Lee-
dc.identifier.doi10.4082/kjfm.2012.33.4.205-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02716-
dc.contributor.localIdA03196-
dc.contributor.localIdA04428-
dc.contributor.localIdA03203-
dc.relation.journalcodeJ02007-
dc.contributor.alternativeNameLee, Duk Chul-
dc.contributor.alternativeNameLee, Jee Yon-
dc.contributor.alternativeNameLee, Ji Won-
dc.contributor.alternativeNameHong, Jung Ah-
dc.contributor.affiliatedAuthorLee, Duk Chul-
dc.contributor.affiliatedAuthorLee, Jee Yon-
dc.contributor.affiliatedAuthorHong, Jung Ah-
dc.contributor.affiliatedAuthorLee, Ji Won-
dc.citation.volume33-
dc.citation.number4-
dc.citation.startPage205-
dc.citation.endPage210-
dc.identifier.bibliographicCitationKorean Journal of Family Medicine, Vol.33(4) : 205-210, 2012-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실)

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