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Serum Ferritin Is Differentially Associated with Anti-oxidative Status and Insulin Resistance in Healthy Obese and Non-obese Women.
DC Field | Value | Language |
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dc.contributor.author | 이덕철 | - |
dc.contributor.author | 이지연 | - |
dc.contributor.author | 이지원 | - |
dc.contributor.author | 홍정아 | - |
dc.contributor.author | 박재민 | - |
dc.date.accessioned | 2014-12-19T17:50:48Z | - |
dc.date.available | 2014-12-19T17:50:48Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 2005-6443 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92168 | - |
dc.description.abstract | BACKGROUND: Ferritin is known to be associated with insulin resistance (IR) and oxidative stress; however, recent studies have shown that there is an association between ferritin and anti-oxidative status. To date, the biphasic response of ferritin to oxidative stress has not been fully evaluated. Thus, we investigated the association between ferritin and IR and anti-oxidative status in obese and non-obese women. METHODS: We evaluated the homeostasis model assessment of insulin resistance (HOMA-IR) and total anti-oxidant status (TAS) in a total of 111 healthy women between the ages of 32 and 68 years. RESULTS: In all of the study subjects, ferritin levels were positively correlated with age (r = 0.38, P < 0.001), body mass index (r = 0.24, P = 0.01), TAS (r = 0.38, P < 0.001) and HOMA-IR (r = 0.20, P = 0.04). In the subgroup analysis, ferritin levels were correlated with age (r = 0.39, P < 0.001) and TAS (r = 0.43, P < 0.001) in the non-obese group and with insulin (r = 0.50, P = 0.02) and HOMA-IR (r = 0.52, P = 0.01) levels in the obese group. On stepwise multiple linear regression analysis, ferritin was found to be independently associated with TAS (B = 177.16, P < 0.0001) in the non-obese group and independently associated with HOMA-IR (B = 30.36, P = 0.01) in the obese group. CONCLUSION: Our findings suggest ferritin is associated with IR in obese women and with anti-oxidative status in non-obese women. Further studies are warranted to elucidate the precise role of ferritin in obesity. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | 대한가정의학회 | - |
dc.relation.isPartOf | Korean Journal of Family Medicine (가정의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Serum Ferritin Is Differentially Associated with Anti-oxidative Status and Insulin Resistance in Healthy Obese and Non-obese Women. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학) | - |
dc.contributor.googleauthor | Jee-Yon Lee | - |
dc.contributor.googleauthor | Jae-Min Park | - |
dc.contributor.googleauthor | Jung-Ah Hong | - |
dc.contributor.googleauthor | Duk-Chul Lee | - |
dc.contributor.googleauthor | Jee-Aee Im | - |
dc.contributor.googleauthor | Ji-Won Lee | - |
dc.identifier.doi | 22916322 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02716 | - |
dc.contributor.localId | A03196 | - |
dc.contributor.localId | A04428 | - |
dc.contributor.localId | A03203 | - |
dc.relation.journalcode | J02007 | - |
dc.identifier.eissn | 2092-6715 | - |
dc.identifier.pmid | 22916322 | - |
dc.subject.keyword | Ferritins | - |
dc.subject.keyword | Obesity | - |
dc.subject.keyword | Oxidative Stress | - |
dc.contributor.alternativeName | Lee, Duk Chul | - |
dc.contributor.alternativeName | Lee, Jee Yon | - |
dc.contributor.alternativeName | Lee, Ji Won | - |
dc.contributor.alternativeName | Hong, Jung Ah | - |
dc.contributor.affiliatedAuthor | Lee, Duk Chul | - |
dc.contributor.affiliatedAuthor | Lee, Jee Yon | - |
dc.contributor.affiliatedAuthor | Hong, Jung Ah | - |
dc.contributor.affiliatedAuthor | Lee, Ji Won | - |
dc.citation.volume | 33 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 205 | - |
dc.citation.endPage | 210 | - |
dc.identifier.bibliographicCitation | Korean Journal of Family Medicine, Vol.33(4) : 205-210, 2012 | - |
dc.identifier.rimsid | 29658 | - |
dc.type.rims | ART | - |
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