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Serum Retinol-Binding Protein-4 Levels Are Increased in HIV-Infected Subjects with Metabolic Syndrome Receiving Highly Active Antiretroviral Therapy

 Su Jin Jeong  ;  Bum Sik Chin  ;  Yun Tae Chae  ;  Sung Joon Jin  ;  Nam Su Ku  ;  Ji Hyeon Baek  ;  Sang Hoon Han  ;  Chang Oh Kim  ;  Jun Yong Choi  ;  Young Goo Song  ;  Hyun Chul Lee  ;  June Myung Kim 
 YONSEI MEDICAL JOURNAL, Vol.53(6) : 1211-1215, 2012 
Journal Title
Issue Date
Adult ; Antiretroviral Therapy, Highly Active* ; Enzyme-Linked Immunosorbent Assay ; Female ; HIV Infections/blood* ; HIV Infections/drug therapy* ; Humans ; Male ; Metabolic Syndrome/blood* ; Metabolic Syndrome/drug therapy* ; Middle Aged ; Retinol-Binding Proteins, Plasma/metabolism*
Retinol-binding protein-4 ; metabolic syndrome ; HIV ; highly active antiretroviral therapy
Metabolic syndrome is an important long term complication in chronic asymptomatic HIV-infected subjects under highly active antiretroviral therapy (HAART), because it can contribute to morbidity and mortality via cardiovascular disease (CVD). Therefore, a predictive marker for early detection of metabolic syndrome may be necessary to prevent CVD in HIV-infected subjects. Retinol-binding protein-4 (RBP-4) has been shown to be associated with metabolic syndrome in various non-HIV-infected populations. We performed a cross-sectional study to evaluate whether serum RBP-4 levels are correlated with metabolic syndrome in HIV-infected subjects receiving HAART. In total, 98 HIV-infected Koreans who had been receiving HAART for at least 6 months were prospectively enrolled. Metabolic syndrome was diagnosed according to the Adult Treatment Panel III criteria, and serum RBP-4 concentrations were measured using human RBP-4 sandwich enzyme-linked immunosorbent assay. Serum RBP-4 levels were significantly higher in HIV-infected subjects receiving HAART with metabolic syndrome (n=33, 33.9±7.7 µg/mL) than in those without it (n=65, 29.9±7.2 µg/mL) (p=0.012). In multivariate linear regression analysis, the number of components of metabolic syndrome presented and waist circumference were independently, significantly correlated with RBP-4 (p=0.018 and 0.030, respectively). In conclusion, we revealed a strong correlation between RBP-4 and the number of components of metabolic syndrome in HIV-infected subjects receiving HAART.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Baek, Ji Hyeon(백지현)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Lee, Hyun Chul(이현철)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Chin, Bum Sik(진범식)
Jin, Sung Joon(진성준)
Chae, Yun Tae(채윤태)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
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