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Serum Retinol-Binding Protein-4 Levels Are Increased in HIV-Infected Subjects with Metabolic Syndrome Receiving Highly Active Antiretroviral Therapy

Authors
 Su Jin Jeong  ;  Bum Sik Chin  ;  Yun Tae Chae  ;  Sung Joon Jin  ;  Nam Su Ku  ;  Ji Hyeon Baek  ;  Sang Hoon Han  ;  Chang Oh Kim  ;  Jun Yong Choi  ;  Young Goo Song  ;  Hyun Chul Lee  ;  June Myung Kim 
Citation
 Yonsei Medical Journal, Vol.53(6) : 1211-1215, 2012 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2012
Abstract
Metabolic syndrome is an important long term complication in chronic asymptomatic HIV-infected subjects under highly active antiretroviral therapy (HAART), because it can contribute to morbidity and mortality via cardiovascular disease (CVD). Therefore, a predictive marker for early detection of metabolic syndrome may be necessary to prevent CVD in HIV-infected subjects. Retinol-binding protein-4 (RBP-4) has been shown to be associated with metabolic syndrome in various non-HIV-infected populations. We performed a cross-sectional study to evaluate whether serum RBP-4 levels are correlated with metabolic syndrome in HIV-infected subjects receiving HAART. In total, 98 HIV-infected Koreans who had been receiving HAART for at least 6 months were prospectively enrolled. Metabolic syndrome was diagnosed according to the Adult Treatment Panel III criteria, and serum RBP-4 concentrations were measured using human RBP-4 sandwich enzyme-linked immunosorbent assay. Serum RBP-4 levels were significantly higher in HIV-infected subjects receiving HAART with metabolic syndrome (n=33, 33.9±7.7 µg/mL) than in those without it (n=65, 29.9±7.2 µg/mL) (p=0.012). In multivariate linear regression analysis, the number of components of metabolic syndrome presented and waist circumference were independently, significantly correlated with RBP-4 (p=0.018 and 0.030, respectively). In conclusion, we revealed a strong correlation between RBP-4 and the number of components of metabolic syndrome in HIV-infected subjects receiving HAART.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92164
DOI
10.3349/ymj.2012.53.6.1211
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김준명(Kim, June Myung) ; 김창오(Kim, Chang Oh) ; 백지현(Baek, Ji Hyeon) ; 송영구(Song, Young Goo) ; 이현철(Lee, Hyun Chul) ; 정수진(Jeong, Su Jin) ; 진범식(Chin, Bum Sik) ; 진성준(Jin, Sung Joon) ; 채윤태(Chae, Yun Tae) ; 최준용(Choi, Jun Yong) ; 한상훈(Han, Sang Hoon)
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