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Serum Retinol-Binding Protein-4 Levels Are Increased in HIV-Infected Subjects with Metabolic Syndrome Receiving Highly Active Antiretroviral Therapy
DC Field | Value | Language |
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dc.contributor.author | 진성준 | - |
dc.contributor.author | 김준명 | - |
dc.contributor.author | 채윤태 | - |
dc.contributor.author | 김창오 | - |
dc.contributor.author | 최준용 | - |
dc.contributor.author | 백지현 | - |
dc.contributor.author | 한상훈 | - |
dc.contributor.author | 송영구 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 진범식 | - |
dc.date.accessioned | 2014-12-19T17:50:40Z | - |
dc.date.available | 2014-12-19T17:50:40Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92164 | - |
dc.description.abstract | Metabolic syndrome is an important long term complication in chronic asymptomatic HIV-infected subjects under highly active antiretroviral therapy (HAART), because it can contribute to morbidity and mortality via cardiovascular disease (CVD). Therefore, a predictive marker for early detection of metabolic syndrome may be necessary to prevent CVD in HIV-infected subjects. Retinol-binding protein-4 (RBP-4) has been shown to be associated with metabolic syndrome in various non-HIV-infected populations. We performed a cross-sectional study to evaluate whether serum RBP-4 levels are correlated with metabolic syndrome in HIV-infected subjects receiving HAART. In total, 98 HIV-infected Koreans who had been receiving HAART for at least 6 months were prospectively enrolled. Metabolic syndrome was diagnosed according to the Adult Treatment Panel III criteria, and serum RBP-4 concentrations were measured using human RBP-4 sandwich enzyme-linked immunosorbent assay. Serum RBP-4 levels were significantly higher in HIV-infected subjects receiving HAART with metabolic syndrome (n=33, 33.9±7.7 µg/mL) than in those without it (n=65, 29.9±7.2 µg/mL) (p=0.012). In multivariate linear regression analysis, the number of components of metabolic syndrome presented and waist circumference were independently, significantly correlated with RBP-4 (p=0.018 and 0.030, respectively). In conclusion, we revealed a strong correlation between RBP-4 and the number of components of metabolic syndrome in HIV-infected subjects receiving HAART. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antiretroviral Therapy, Highly Active* | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | HIV Infections/blood* | - |
dc.subject.MESH | HIV Infections/drug therapy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolic Syndrome/blood* | - |
dc.subject.MESH | Metabolic Syndrome/drug therapy* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Retinol-Binding Proteins, Plasma/metabolism* | - |
dc.title | Serum Retinol-Binding Protein-4 Levels Are Increased in HIV-Infected Subjects with Metabolic Syndrome Receiving Highly Active Antiretroviral Therapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Su Jin Jeong | - |
dc.contributor.googleauthor | Bum Sik Chin | - |
dc.contributor.googleauthor | Yun Tae Chae | - |
dc.contributor.googleauthor | Sung Joon Jin | - |
dc.contributor.googleauthor | Nam Su Ku | - |
dc.contributor.googleauthor | Ji Hyeon Baek | - |
dc.contributor.googleauthor | Sang Hoon Han | - |
dc.contributor.googleauthor | Chang Oh Kim | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Young Goo Song | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | June Myung Kim | - |
dc.identifier.doi | 23074124 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03983 | - |
dc.contributor.localId | A00953 | - |
dc.contributor.localId | A04022 | - |
dc.contributor.localId | A01044 | - |
dc.contributor.localId | A04191 | - |
dc.contributor.localId | A01839 | - |
dc.contributor.localId | A04286 | - |
dc.contributor.localId | A02037 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03638 | - |
dc.contributor.localId | A03981 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 23074124 | - |
dc.subject.keyword | Retinol-binding protein-4 | - |
dc.subject.keyword | metabolic syndrome | - |
dc.subject.keyword | HIV | - |
dc.subject.keyword | highly active antiretroviral therapy | - |
dc.contributor.alternativeName | Jin, Sung Joon | - |
dc.contributor.alternativeName | Kim, June Myung | - |
dc.contributor.alternativeName | Chae, Yun Tae | - |
dc.contributor.alternativeName | Kim, Chang Oh | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.alternativeName | Baek, Ji Hyeon | - |
dc.contributor.alternativeName | Han, Sang Hoon | - |
dc.contributor.alternativeName | Song, Young Goo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Jeong, Su Jin | - |
dc.contributor.alternativeName | Chin, Bum Sik | - |
dc.contributor.affiliatedAuthor | Jin, Sung Joon | - |
dc.contributor.affiliatedAuthor | Kim, June Myung | - |
dc.contributor.affiliatedAuthor | Chae, Yun Tae | - |
dc.contributor.affiliatedAuthor | Kim, Chang Oh | - |
dc.contributor.affiliatedAuthor | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | Baek, Ji Hyeon | - |
dc.contributor.affiliatedAuthor | Han, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Song, Young Goo | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Jeong, Su Jin | - |
dc.contributor.affiliatedAuthor | Chin, Bum Sik | - |
dc.citation.volume | 53 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1211 | - |
dc.citation.endPage | 1215 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.53(6) : 1211-1215, 2012 | - |
dc.identifier.rimsid | 29655 | - |
dc.type.rims | ART | - |
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