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Serum Retinol-Binding Protein-4 Levels Are Increased in HIV-Infected Subjects with Metabolic Syndrome Receiving Highly Active Antiretroviral Therapy

DC FieldValueLanguage
dc.contributor.author진성준-
dc.contributor.author김준명-
dc.contributor.author채윤태-
dc.contributor.author김창오-
dc.contributor.author최준용-
dc.contributor.author백지현-
dc.contributor.author한상훈-
dc.contributor.author송영구-
dc.contributor.author이현철-
dc.contributor.author정수진-
dc.contributor.author진범식-
dc.date.accessioned2014-12-19T17:50:40Z-
dc.date.available2014-12-19T17:50:40Z-
dc.date.issued2012-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92164-
dc.description.abstractMetabolic syndrome is an important long term complication in chronic asymptomatic HIV-infected subjects under highly active antiretroviral therapy (HAART), because it can contribute to morbidity and mortality via cardiovascular disease (CVD). Therefore, a predictive marker for early detection of metabolic syndrome may be necessary to prevent CVD in HIV-infected subjects. Retinol-binding protein-4 (RBP-4) has been shown to be associated with metabolic syndrome in various non-HIV-infected populations. We performed a cross-sectional study to evaluate whether serum RBP-4 levels are correlated with metabolic syndrome in HIV-infected subjects receiving HAART. In total, 98 HIV-infected Koreans who had been receiving HAART for at least 6 months were prospectively enrolled. Metabolic syndrome was diagnosed according to the Adult Treatment Panel III criteria, and serum RBP-4 concentrations were measured using human RBP-4 sandwich enzyme-linked immunosorbent assay. Serum RBP-4 levels were significantly higher in HIV-infected subjects receiving HAART with metabolic syndrome (n=33, 33.9±7.7 µg/mL) than in those without it (n=65, 29.9±7.2 µg/mL) (p=0.012). In multivariate linear regression analysis, the number of components of metabolic syndrome presented and waist circumference were independently, significantly correlated with RBP-4 (p=0.018 and 0.030, respectively). In conclusion, we revealed a strong correlation between RBP-4 and the number of components of metabolic syndrome in HIV-infected subjects receiving HAART.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAntiretroviral Therapy, Highly Active*-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFemale-
dc.subject.MESHHIV Infections/blood*-
dc.subject.MESHHIV Infections/drug therapy*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMetabolic Syndrome/blood*-
dc.subject.MESHMetabolic Syndrome/drug therapy*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetinol-Binding Proteins, Plasma/metabolism*-
dc.titleSerum Retinol-Binding Protein-4 Levels Are Increased in HIV-Infected Subjects with Metabolic Syndrome Receiving Highly Active Antiretroviral Therapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorBum Sik Chin-
dc.contributor.googleauthorYun Tae Chae-
dc.contributor.googleauthorSung Joon Jin-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorJi Hyeon Baek-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorChang Oh Kim-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorHyun Chul Lee-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi23074124-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03983-
dc.contributor.localIdA00953-
dc.contributor.localIdA04022-
dc.contributor.localIdA01044-
dc.contributor.localIdA04191-
dc.contributor.localIdA01839-
dc.contributor.localIdA04286-
dc.contributor.localIdA02037-
dc.contributor.localIdA03301-
dc.contributor.localIdA03638-
dc.contributor.localIdA03981-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid23074124-
dc.subject.keywordRetinol-binding protein-4-
dc.subject.keywordmetabolic syndrome-
dc.subject.keywordHIV-
dc.subject.keywordhighly active antiretroviral therapy-
dc.contributor.alternativeNameJin, Sung Joon-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameChae, Yun Tae-
dc.contributor.alternativeNameKim, Chang Oh-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameBaek, Ji Hyeon-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameChin, Bum Sik-
dc.contributor.affiliatedAuthorJin, Sung Joon-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorChae, Yun Tae-
dc.contributor.affiliatedAuthorKim, Chang Oh-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorBaek, Ji Hyeon-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorChin, Bum Sik-
dc.citation.volume53-
dc.citation.number6-
dc.citation.startPage1211-
dc.citation.endPage1215-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.53(6) : 1211-1215, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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