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A direct inhibitory effect of botulinum toxin type A on antral circular muscle contractility of guinea pig

Authors
 Jung Ho Park  ;  EunJoo Choi  ;  Hyojin Park  ;  Yong Ho Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.53(5) : 968-973, 2012 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2012
MeSH
Animals ; Botulinum Toxins, Type A/pharmacology* ; Guinea Pigs ; In Vitro Techniques ; Muscle Contraction/drug effects* ; Pyloric Antrum/drug effects
Keywords
Botulinum toxin type A ; electrical field stimulation ; gastric antrum
Abstract
PURPOSE: Recent studies suggest new mechanisms of Botulinum toxin (BoNT) other than inhibiting acetylcholine (ACh) release from nerve terminals. The aim of this study was to determine whether other mechanisms for BoNT exist, so that it directly inhibits smooth muscle contraction.

MATERIALS AND METHODS: Guinea pig antral muscle strips were studied in vitro after 2 hours of exposure to Botulinum toxin type A (BoNT/A). Contractile responses to electric field stimulation (EFS), high K(+) (60 mM) and ACh (100 μM) were evaluated 24 and 48 hours after antral intramuscular injection of BoNT/A or vehicle.

RESULTS: BoNT/A inhibited muscular contraction caused by high K(+) and ACh. Contractile responses to low (1 and 4 Hz) and high (8 and 20 Hz) frequency EFS of antral muscle strips 24 and 48 hours after antral intramuscular injection of BoNT/A were significantly inhibited.

CONCLUSION: The ability of BoNT/A to directly inhibit antral muscular contractility suggests a new mechanism for the pharmacologic actions of BoNT-direct inhibition of muscular contraction.
Files in This Item:
T201202424.pdf Download
DOI
10.3349/ymj.2012.53.5.968
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Lee, Young Ho(이영호) ORCID logo https://orcid.org/0000-0002-5749-1045
Choi, Eun Joo(최은주)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92109
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