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A direct inhibitory effect of botulinum toxin type A on antral circular muscle contractility of guinea pig
DC Field | Value | Language |
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dc.contributor.author | 박효진 | - |
dc.contributor.author | 이영호 | - |
dc.contributor.author | 최은주 | - |
dc.date.accessioned | 2014-12-19T17:48:51Z | - |
dc.date.available | 2014-12-19T17:48:51Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92109 | - |
dc.description.abstract | PURPOSE: Recent studies suggest new mechanisms of Botulinum toxin (BoNT) other than inhibiting acetylcholine (ACh) release from nerve terminals. The aim of this study was to determine whether other mechanisms for BoNT exist, so that it directly inhibits smooth muscle contraction. MATERIALS AND METHODS: Guinea pig antral muscle strips were studied in vitro after 2 hours of exposure to Botulinum toxin type A (BoNT/A). Contractile responses to electric field stimulation (EFS), high K(+) (60 mM) and ACh (100 μM) were evaluated 24 and 48 hours after antral intramuscular injection of BoNT/A or vehicle. RESULTS: BoNT/A inhibited muscular contraction caused by high K(+) and ACh. Contractile responses to low (1 and 4 Hz) and high (8 and 20 Hz) frequency EFS of antral muscle strips 24 and 48 hours after antral intramuscular injection of BoNT/A were significantly inhibited. CONCLUSION: The ability of BoNT/A to directly inhibit antral muscular contractility suggests a new mechanism for the pharmacologic actions of BoNT-direct inhibition of muscular contraction. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Botulinum Toxins, Type A/pharmacology* | - |
dc.subject.MESH | Guinea Pigs | - |
dc.subject.MESH | In Vitro Techniques | - |
dc.subject.MESH | Muscle Contraction/drug effects* | - |
dc.subject.MESH | Pyloric Antrum/drug effects | - |
dc.title | A direct inhibitory effect of botulinum toxin type A on antral circular muscle contractility of guinea pig | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Jung Ho Park | - |
dc.contributor.googleauthor | EunJoo Choi | - |
dc.contributor.googleauthor | Hyojin Park | - |
dc.contributor.googleauthor | Yong Ho Lee | - |
dc.identifier.doi | 22869480 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01774 | - |
dc.contributor.localId | A02968 | - |
dc.contributor.localId | A04159 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 22869480 | - |
dc.subject.keyword | Botulinum toxin type A | - |
dc.subject.keyword | electrical field stimulation | - |
dc.subject.keyword | gastric antrum | - |
dc.contributor.alternativeName | Park, Hyo Jin | - |
dc.contributor.alternativeName | Lee, Young Ho | - |
dc.contributor.alternativeName | Choi, Eun Joo | - |
dc.contributor.affiliatedAuthor | Park, Hyo Jin | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Choi, Eun Joo | - |
dc.citation.volume | 53 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 968 | - |
dc.citation.endPage | 973 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.53(5) : 968-973, 2012 | - |
dc.identifier.rimsid | 29621 | - |
dc.type.rims | ART | - |
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