Cited 19 times in
Prediction of thrombus resolution after intravenous thrombolysis assessed by CT-based thrombus imaging
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김응엽 | - |
dc.contributor.author | 김진권 | - |
dc.contributor.author | 남정모 | - |
dc.contributor.author | 남효석 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 허지회 | - |
dc.contributor.author | 김영대 | - |
dc.date.accessioned | 2014-12-19T17:42:57Z | - |
dc.date.available | 2014-12-19T17:42:57Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0340-6245 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91918 | - |
dc.description.abstract | The degree of thrombus resolution directly indicates the effectiveness of a thrombolytic drug. We investigated the degree of thrombus resolution and factors associated with thrombus resolution after intravenous (IV) recombinant tissue plasminogen activator (rt-PA) using thin-section noncontrast computed tomography (NCT). Thin-section NCTs were performed before and immediately after IV rt-PA infusion in acute stroke patients. The thrombus volume and Hounsfield unit were measured using three-dimensional imaging software. Immediate recanalisation was assessed immediately after IV rt-PA infusion using CT angiography. During a three-year study period, 130 patients were prospectively enrolled. On baseline thin-section NCT, no thrombi were found in 30 patients (23%). Among the 100 patients with confirmed thrombus, the median volume decreased by 20% on the follow-up NCT. The thrombus was completely resolved in 8%. Of note, an increase in thrombus volume was observed in 20 patients. Independent predictors of thrombus resolution were total rt-PA dose, thrombus location in the M2 segment of the middle cerebral artery, and time from baseline to follow-up NCT. Thrombus resolution increased by 9% per each 10-mg increase in rt-PA (p = 0.045). Immediate complete recanalisation was achieved in 12% of patients. Total dose of rt-PA was independently associated with complete recanalisation [odds ratio [OR] 4.52, 95% confidence interval [CI] 1.345-15.184) and good functional outcome at three months (modified Rankin scale score <3, OR 2.34, 95% CI 1.104-4.962). In conclusion, rt-PA dose was associated with the degree of thrombus resolution, immediate complete recanalisation, and good outcome at three months. CT-based thrombus imaging may be helpful in determining thrombolysis effectiveness. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | THROMBOSIS AND HAEMOSTASIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Cerebrovascular Disorders/diagnosis* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ischemia/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Middle Cerebral Artery/pathology | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Software | - |
dc.subject.MESH | Stroke/pathology | - |
dc.subject.MESH | Thrombolytic Therapy/methods* | - |
dc.subject.MESH | Thrombosis/therapy* | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Tissue Plasminogen Activator/metabolism | - |
dc.subject.MESH | Tomography, X-Ray Computed/methods* | - |
dc.title | Prediction of thrombus resolution after intravenous thrombolysis assessed by CT-based thrombus imaging | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | H. S. Nam | - |
dc.contributor.googleauthor | E. Y. Kim | - |
dc.contributor.googleauthor | S. H. Kim | - |
dc.contributor.googleauthor | Y. D. Kim | - |
dc.contributor.googleauthor | J. Kim | - |
dc.contributor.googleauthor | H. S. Lee | - |
dc.contributor.googleauthor | C. M. Nam | - |
dc.contributor.googleauthor | J. H. Heo | - |
dc.identifier.doi | 10.1160/TH11-08-0585 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00832 | - |
dc.contributor.localId | A01012 | - |
dc.contributor.localId | A01264 | - |
dc.contributor.localId | A01273 | - |
dc.contributor.localId | A04369 | - |
dc.contributor.localId | A00702 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J02728 | - |
dc.identifier.pmid | 22318312 | - |
dc.identifier.url | http://www.schattauer.de/en/magazine/subject-areas/journals-a-z/thrombosis-and-haemostasis/contents/archive/issue/1526/manuscript/17250.html | - |
dc.subject.keyword | Computed tomography | - |
dc.subject.keyword | thrombus | - |
dc.subject.keyword | thrombolytic therapy | - |
dc.subject.keyword | cerebrovascular disease | - |
dc.contributor.alternativeName | Kim, Eung Yeop | - |
dc.contributor.alternativeName | Kim, Jin Kwon | - |
dc.contributor.alternativeName | Nam, Jung Mo | - |
dc.contributor.alternativeName | Nam, Hyo Suk | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.alternativeName | Kim, Young Dae | - |
dc.contributor.affiliatedAuthor | Kim, Eung Yeop | - |
dc.contributor.affiliatedAuthor | Kim, Jin Kwon | - |
dc.contributor.affiliatedAuthor | Nam, Jung Mo | - |
dc.contributor.affiliatedAuthor | Nam, Hyo Suk | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Kim, Young Dae | - |
dc.contributor.affiliatedAuthor | Lee, Hye Sun | - |
dc.citation.volume | 107 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 786 | - |
dc.citation.endPage | 794 | - |
dc.identifier.bibliographicCitation | THROMBOSIS AND HAEMOSTASIS, Vol.107(4) : 786-794, 2012 | - |
dc.identifier.rimsid | 30006 | - |
dc.type.rims | ART | - |
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