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Ramosetron, dexamethasone, and their combination for the prevention of postoperative nausea and vomiting in women undergoing laparoscopic cholecystectomy

 Youn Yi Jo  ;  Jong Wha Lee  ;  Jae Kwang Shim  ;  Woo Kyung Lee  ;  Yong Seon Choi 
 Surgical Endoscopy , Vol.26(8) : 2306-2311, 2012 
Journal Title
 Surgical Endoscopy  
Issue Date
Adult ; Antiemetics/administration & dosage* ; Benzimidazoles/administration & dosage* ; Cholecystectomy, Laparoscopic/adverse effects* ; Dexamethasone/administration & dosage* ; Double-Blind Method ; Drug Therapy, Combination/methods ; Female ; Humans ; Middle Aged ; Postoperative Nausea and Vomiting/prevention & control* ; Prospective Studies ; Treatment Outcome ; Young Adult
PONV ; Ramosetron ; Dexamethasone ; Laparoscopic cholecystectomy
BACKGROUND: In this randomized and controlled study, we evaluated the antiemetic efficacy of ramosetron combined with dexamethasone for postoperative nausea and vomiting (PONV) compared with that of dexamethasone or ramosetron alone in women who underwent laparoscopic cholecystectomy. METHODS: One hundred twenty female patients were randomly assigned to one of three groups to receive antiemetics as follows: ramosetron 0.3 mg (group R), dexamethasone 8 mg (group D), or ramosetron 0.3 mg combined with dexamethasone 8 mg (group RD). PONV, postoperative pain intensity, rescue antiemetics requirement, and side effects were assessed at 0-6, 6-12, and 12-24 h after surgery. RESULTS: The ratio of complete response (no PONV and no rescue antiemetic) was higher at 6-12 h in groups R and RD than in group D (p < 0.05) and at 12-24 h in group RD than in group D (p < 0.05). The incidence of nausea was lower at 6-12 h in groups R (p = 0.043) and RD (p = 0.003) compared to group D and at 12-24 h in group RD (p = 0.01) compared to group D. The severity of nausea was also significantly reduced at 6-12 h in groups R and RD compared to group D (p < 0.05). There were no clinically serious adverse events related to the studied drugs. CONCLUSION: Antiemetic efficacy of the combination of ramosetron 0.3 mg and dexamethasone 8 mg for PONV was most superior, with 93% of the patients showing complete response at 12-24 h after surgery followed by ramosetron alone and dexamethasone alone.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Shim, Jae Kwang(심재광) ORCID logo https://orcid.org/0000-0001-9093-9692
Lee, Woo Kyung(이우경)
Lee, Jong Wha(이종화)
Jo, Youn Yi(조윤이)
Choi, Yong Seon(최용선) ORCID logo https://orcid.org/0000-0002-5348-864X
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