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Body image, sexual function and depression in Korean patients with breast cancer: modification by 5-HTT polymorphism

Authors
 Kyung Ran Kim ; Hyun Cheol Chung ; Kee Namkoong ; Se Joo Kim ; Eun Lee 
Citation
 Supportive Care in Cancer, Vol.20(9) : 2177~2182, 2012 
Journal Title
 Supportive Care in Cancer 
ISSN
 0941-4355 
Issue Date
2012
Abstract
BACKGROUND: Nearly 50% of women with breast cancer show depressive symptoms after diagnosis and treatment. The purpose of this study was to clarify how psychosocial factors (body image, sexuality, and social relationships) and genetic factors (functional polymorphism of the serotonin transporter-linked promoter region) influence depression. METHODS: The participants were categorized by DSM-IV diagnoses; scored according to their depressive symptoms, body image and social and sexual function (BIRS), self-esteem, and quality of life; and genotyped by functional polymorphism of the serotonin transporter promoter. RESULTS: Patients with depressive symptoms showed low self-esteem, poor body image, relationship problems, and low quality of life. Genotype frequencies did not differ between two groups categorized by the presence or absence of depressive symptoms. However, the patients with the short allele of the 5-HTTLPR had significantly higher HAM-D scores (F = 7.59, p = 0.047). CONCLUSION: The results suggest that psychosocial factors related to breast cancer treatment such as body image, self-esteem, and interpersonal relationship influence the development of depressive symptoms. The 5-HTTLPR may be associated with the severity of depressive symptoms rather than susceptibility to the development of depressive symptoms.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91888
DOI
10.1007/s00520-011-1329-z
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Psychiatry
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs00520-011-1329-z
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