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Body image, sexual function and depression in Korean patients with breast cancer: modification by 5-HTT polymorphism

 Kyung Ran Kim  ;  Hyun Cheol Chung  ;  Eun Lee  ;  Se Joo Kim  ;  Kee Namkoong 
 Supportive Care in Cancer, Vol.20(9) : 2177-2182, 2012 
Journal Title
 Supportive Care in Cancer 
Issue Date
BACKGROUND: Nearly 50% of women with breast cancer show depressive symptoms after diagnosis and treatment. The purpose of this study was to clarify how psychosocial factors (body image, sexuality, and social relationships) and genetic factors (functional polymorphism of the serotonin transporter-linked promoter region) influence depression. METHODS: The participants were categorized by DSM-IV diagnoses; scored according to their depressive symptoms, body image and social and sexual function (BIRS), self-esteem, and quality of life; and genotyped by functional polymorphism of the serotonin transporter promoter. RESULTS: Patients with depressive symptoms showed low self-esteem, poor body image, relationship problems, and low quality of life. Genotype frequencies did not differ between two groups categorized by the presence or absence of depressive symptoms. However, the patients with the short allele of the 5-HTTLPR had significantly higher HAM-D scores (F = 7.59, p = 0.047). CONCLUSION: The results suggest that psychosocial factors related to breast cancer treatment such as body image, self-esteem, and interpersonal relationship influence the development of depressive symptoms. The 5-HTTLPR may be associated with the severity of depressive symptoms rather than susceptibility to the development of depressive symptoms.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
Yonsei Authors
김경란(Kim, Kyung Ran)
김세주(Kim, Se Joo)
남궁기(Namkoong, Kee)
이은(Lee, Eun)
정현철(Chung, Hyun Cheol)
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