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Body image, sexual function and depression in Korean patients with breast cancer: modification by 5-HTT polymorphism

Authors
 Kyung Ran Kim  ;  Hyun Cheol Chung  ;  Eun Lee  ;  Se Joo Kim  ;  Kee Namkoong 
Citation
 SUPPORTIVE CARE IN CANCER, Vol.20(9) : 2177-2182, 2012 
Journal Title
 SUPPORTIVE CARE IN CANCER 
ISSN
 0941-4355 
Issue Date
2012
Keywords
Breast cancer ; Depression ; Body image ; 5-HTTLPR
Abstract
BACKGROUND: Nearly 50% of women with breast cancer show depressive symptoms after diagnosis and treatment. The purpose of this study was to clarify how psychosocial factors (body image, sexuality, and social relationships) and genetic factors (functional polymorphism of the serotonin transporter-linked promoter region) influence depression. METHODS: The participants were categorized by DSM-IV diagnoses; scored according to their depressive symptoms, body image and social and sexual function (BIRS), self-esteem, and quality of life; and genotyped by functional polymorphism of the serotonin transporter promoter. RESULTS: Patients with depressive symptoms showed low self-esteem, poor body image, relationship problems, and low quality of life. Genotype frequencies did not differ between two groups categorized by the presence or absence of depressive symptoms. However, the patients with the short allele of the 5-HTTLPR had significantly higher HAM-D scores (F = 7.59, p = 0.047). CONCLUSION: The results suggest that psychosocial factors related to breast cancer treatment such as body image, self-esteem, and interpersonal relationship influence the development of depressive symptoms. The 5-HTTLPR may be associated with the severity of depressive symptoms rather than susceptibility to the development of depressive symptoms.
Full Text
http://link.springer.com/article/10.1007%2Fs00520-011-1329-z
DOI
10.1007/s00520-011-1329-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Ran(김경란) ORCID logo https://orcid.org/0000-0001-8375-1851
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91888
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