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The effect of bilateral globus pallidus internus deep brain stimulation plus ventralis oralis thalamotomy on patients with cerebral palsy

Authors
 Kim J.P.  ;  Chang W.S.  ;  Cho S.-R.  ;  Chang J.W. 
Citation
 STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, Vol.1(90) : 292-299, 2012 
Journal Title
 STEREOTACTIC AND FUNCTIONAL NEUROSURGERY 
ISSN
 1011-6125 
Issue Date
2012
MeSH
Adolescent ; Adult ; Cerebral Palsy/physiopathology* ; Cerebral Palsy/surgery ; Cerebral Palsy/therapy* ; Deep Brain Stimulation/methods* ; Female ; Follow-Up Studies ; Globus Pallidus/physiology* ; Humans ; Male ; Quality of Life/psychology ; Thalamus/physiopathology* ; Thalamus/surgery ; Treatment Outcome ; Ventral Thalamic Nuclei/physiopathology ; Ventral Thalamic Nuclei/surgery ; Young Adult
Keywords
Ventralis oralis anterior ; Cerebral palsy ; Deep brain stimulation ; Globus pallidus internus ; Thalamotomy
Abstract
OBJECTIVE: We compared bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) with bilateral GPi DBS plus ventralis oralis (Vo) thalamotomy to analyze the effect of the combined Vo thalamotomy. METHODS: Between March 2003 and December 2008, 10 patients underwent DBS and/or Vo thalamotomy for treatment of cerebral palsy in our institute of neurosurgery and rehabilitation medicine. Four patients received bilateral posteroventral GPi DBS as group I and 6 patients received GPi DBS plus unilateral thalamotomy as group II. RESULTS: The movement and disability scores of group I improved by 32 and 14.3%, respectively, at the last follow-up compared with baseline. The movement and disability scores of group II improved by 31.5 and 0.18%. The BFMDRS-movement subscores of group II demonstrated statistically significant improvement in the contralateral arm compared to group I (p = 0.042). Body pain, vitality and mental health seemed to improve in group II, in terms of health-related quality of life. CONCLUSIONS: Contrary to our expectations, we were unable to demonstrate clear improvements in overall BFMDRS scores between group I and group II. However, movements of the contralateral upper extremities improved and health-related quality of life in group II showed satisfactory results.
Full Text
http://www.karger.com/Article/FullText/338093
DOI
22797720
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Pyung(김주평)
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Cho, Sung-Rae(조성래) ORCID logo https://orcid.org/0000-0003-1429-2684
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91880
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