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Red blood cell distribution width is an independent predictor of mortality in patients with gram-negative bacteremia

Authors
 Ku, Nam Su  ;  Kim, Hye-won  ;  Choi, Jun Yong  ;  Kim, June Myung  ;  Song, Young Goo  ;  Kim, Chang Oh  ;  Han, Sang Hoon  ;  Jeong, Su Jin  ;  Kim, Sun Bean  ;  Ahn, Jin Young  ;  Oh, Dong Hyun  ;  Song, Je Eun  ;  Kim, Min Hyung  ;  Kim, Yong Chan  ;  Oh, Hyung Jung 
Citation
 Shock, Vol.38(2) : 123-127, 2012 
Journal Title
 Shock 
ISSN
 1073-2322 
Issue Date
2012
Abstract
Red blood cell distribution width (RDW) is known to be a predictor of severe morbidity and mortality in some chronic diseases such as congestive heart failure. However, to our knowledge, little is known about RDW as a predictor of mortality in patients with Gram-negative bacteremia, a major nosocomial cause of intra-abdominal infections, urinary tract infections, and primary bacteremia. Therefore, we investigated whether RDW is an independent predictor of mortality in patients with Gram-negative bacteremia. Clinical characteristics, laboratory parameters, and outcomes of 161 patients with Gram-negative bacteremia from November 2010 to March 2011 diagnosed at Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, were retrospectively analyzed. The main outcome measure was 28-day all-cause mortality. The 28-day mortality rate was significantly higher in the increased RDW group compared with the normal RDW group (P < 0.001). According to multivariate Cox proportional hazard analysis, RDW levels at the onset of bacteremia (per 1% increase, P = 0.036), the Charlson index (per 1-point increase, P < 0.001), and the Sequential Organ Failure Assessment score (per 1-point increase, P = 0.001) were independent risk factors for 28-day mortality. Moreover, the nonsurvivor group had significantly higher RDW levels 72 h after the onset of bacteremia than did the survivor group (P = 0.001). In addition, the area under the curve of RDW at the onset of bacteremia, the 72-h RDW, and the Sequential Organ Failure Assessment score for 28-day mortality were 0.764 (P = 0.001), 0.802 (P < 0.001), and 0.703 (P = 0.008), respectively. Red blood cell distribution width at the onset of bacteremia was an independent predictor of mortality in patients with Gram-negative bacteremia. Also, 72-h RDW could be a predictor for all-cause mortality in patients with Gram-negative bacteremia.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91849
DOI
10.1097/SHK.0b013e31825e2a85
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
구남수(Ku, Nam Su) ; 김민형(Kim, Min Hyung) ; 김선빈(Kim, Sun Bean) ; 김용찬(Kim, Yong Chan) ; 김준명(Kim, June Myung) ; 김창오(Kim, Chang Oh) ; 김혜원(Kim, Hye Won) ; 송영구(Song, Young Goo) ; 송제은(Song, Je Eun) ; 안진영(Ahn, Jin Young) ; 오동현(Oh, Dong Hyun) ; 오형중(Oh, Hyung Jung) ; 정수진(Jeong, Su Jin) ; 최준용(Choi, Jun Yong) ; 한상훈(Han, Sang Hoon)
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