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Red blood cell distribution width is an independent predictor of mortality in patients with gram-negative bacteremia

Authors
 Ku, Nam Su  ;  Kim, Hye-won  ;  Oh, Hyung Jung  ;  Kim, Yong Chan  ;  Kim, Min Hyung  ;  Song, Je Eun  ;  Oh, Dong Hyun  ;  Ahn, Jin Young  ;  Kim, Sun Bean  ;  Jeong, Su Jin  ;  Han, Sang Hoon  ;  Kim, Chang Oh  ;  Song, Young Goo  ;  Kim, June Myung  ;  Choi, Jun Yong 
Citation
 SHOCK, Vol.38(2) : 123-127, 2012 
Journal Title
 SHOCK 
ISSN
 1073-2322 
Issue Date
2012
MeSH
Aged ; Bacteremia/blood ; Bacteremia/mortality* ; Cause of Death ; Erythrocytes, Abnormal/microbiology ; Erythrocytes, Abnormal/pathology* ; Female ; Gram-Negative Bacterial Infections/blood ; Gram-Negative Bacterial Infections/mortality* ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; ROC Curve ; Retrospective Studies ; Risk Factors
Keywords
RDW ; predictor ; mortality ; Gram-negative bacteremia
Abstract
Red blood cell distribution width (RDW) is known to be a predictor of severe morbidity and mortality in some chronic diseases such as congestive heart failure. However, to our knowledge, little is known about RDW as a predictor of mortality in patients with Gram-negative bacteremia, a major nosocomial cause of intra-abdominal infections, urinary tract infections, and primary bacteremia. Therefore, we investigated whether RDW is an independent predictor of mortality in patients with Gram-negative bacteremia. Clinical characteristics, laboratory parameters, and outcomes of 161 patients with Gram-negative bacteremia from November 2010 to March 2011 diagnosed at Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, were retrospectively analyzed. The main outcome measure was 28-day all-cause mortality. The 28-day mortality rate was significantly higher in the increased RDW group compared with the normal RDW group (P < 0.001). According to multivariate Cox proportional hazard analysis, RDW levels at the onset of bacteremia (per 1% increase, P = 0.036), the Charlson index (per 1-point increase, P < 0.001), and the Sequential Organ Failure Assessment score (per 1-point increase, P = 0.001) were independent risk factors for 28-day mortality. Moreover, the nonsurvivor group had significantly higher RDW levels 72 h after the onset of bacteremia than did the survivor group (P = 0.001). In addition, the area under the curve of RDW at the onset of bacteremia, the 72-h RDW, and the Sequential Organ Failure Assessment score for 28-day mortality were 0.764 (P = 0.001), 0.802 (P < 0.001), and 0.703 (P = 0.008), respectively. Red blood cell distribution width at the onset of bacteremia was an independent predictor of mortality in patients with Gram-negative bacteremia. Also, 72-h RDW could be a predictor for all-cause mortality in patients with Gram-negative bacteremia.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00024382-201208000-00002&LSLINK=80&D=ovft
DOI
22683729
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Min Hyung(김민형)
Kim, Sun Bean(김선빈)
Kim, Yong Chan(김용찬)
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Kim, Hye Won(김혜원)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Song, Je Eun(송제은)
Ahn, Jin Young(안진영) ORCID logo https://orcid.org/0000-0002-3740-2826
Oh, Dong Hyun(오동현)
Oh, Hyung Jung(오형중)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91849
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