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Poor correlation between tuberculin skin tests and interferon-γ assays in close contacts of patients with multidrug-resistant tuberculosis

Authors
 KYUNG-WOOK JO  ;  KYEONGMAN JEON  ;  YOUNG AE KANG  ;  WON-JUNG KOH  ;  KYUNG CHAN KIM  ;  YEE HYUNG KIM  ;  KWANG HA YOO  ;  SEUNG HEON LEE  ;  JAE-JOON YIM  ;  SANG BONG CHOI  ;  WON-IL CHOI  ;  JAE CHOL CHOI  ;  YONG IL HWANG  ;  TAE SUN SHIM 
Citation
 Respirology, Vol.17(7) : 1125-1130, 2012 
Journal Title
 Respirology 
ISSN
 1323-7799 
Issue Date
2012
Abstract
BACKGROUND AND OBJECTIVE: The results of tuberculin skin tests (TST) and QuantiFERON TB-Gold In-Tube (QFT-GIT) assays were compared in close contacts of patients with multidrug-resistant tuberculosis (MDR-TB). METHODS: Close contacts of patients with bacteriologically confirmed MDR-TB (n = 101) were assessed. Most contacts were members of the households of patients, and 79 (78.2%) had received Bacille Calmette-Guerin (BCG) vaccination. Samples from each contact were tested using the TST and the QFT-GIT assay on the same day, and the concordance between these results was assessed using kappa (κ) coefficients. RESULTS: Forty-eight subjects (47.5%) showed positive responses on TST, using a 10-mm induration cut-off, and 54 (53.5%) were positive for the QFT-GIT assay. Of the 48 individuals who were TST positive, 34 (70.8%) were positive for the QFT-GIT assay. Of the 53 subjects who were TST negative, 33 (62.5%) were negative for the QFT-GIT assay. The overall agreement between the two tests (κ coefficient) was 0.33. The κ coefficient was higher in the 22 subjects who had not received BCG vaccination (κ = 0.48) than in the 79 subjects who had received BCG vaccination (κ = 0.29). CONCLUSION: The TST and QFT-GIT assays showed poor correlation in close contacts of patients with MDR-TB, especially those contacts who had received BCG vaccination.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91792
DOI
10.1111/j.1440-1843.2012.02218.x
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강영애(Kang, Young Ae)
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