Cited 6 times in
Poor correlation between tuberculin skin tests and interferon-γ assays in close contacts of patients with multidrug-resistant tuberculosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강영애 | - |
dc.date.accessioned | 2014-12-19T17:38:29Z | - |
dc.date.available | 2014-12-19T17:38:29Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1323-7799 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91792 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVE: The results of tuberculin skin tests (TST) and QuantiFERON TB-Gold In-Tube (QFT-GIT) assays were compared in close contacts of patients with multidrug-resistant tuberculosis (MDR-TB). METHODS: Close contacts of patients with bacteriologically confirmed MDR-TB (n = 101) were assessed. Most contacts were members of the households of patients, and 79 (78.2%) had received Bacille Calmette-Guerin (BCG) vaccination. Samples from each contact were tested using the TST and the QFT-GIT assay on the same day, and the concordance between these results was assessed using kappa (κ) coefficients. RESULTS: Forty-eight subjects (47.5%) showed positive responses on TST, using a 10-mm induration cut-off, and 54 (53.5%) were positive for the QFT-GIT assay. Of the 48 individuals who were TST positive, 34 (70.8%) were positive for the QFT-GIT assay. Of the 53 subjects who were TST negative, 33 (62.5%) were negative for the QFT-GIT assay. The overall agreement between the two tests (κ coefficient) was 0.33. The κ coefficient was higher in the 22 subjects who had not received BCG vaccination (κ = 0.48) than in the 79 subjects who had received BCG vaccination (κ = 0.29). CONCLUSION: The TST and QFT-GIT assays showed poor correlation in close contacts of patients with MDR-TB, especially those contacts who had received BCG vaccination. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | RESPIROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interferon-gamma/blood* | - |
dc.subject.MESH | Interferon-gamma Release Tests* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Tuberculin Test/methods* | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/diagnosis* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Poor correlation between tuberculin skin tests and interferon-γ assays in close contacts of patients with multidrug-resistant tuberculosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | KYUNG-WOOK JO | - |
dc.contributor.googleauthor | KYEONGMAN JEON | - |
dc.contributor.googleauthor | YOUNG AE KANG | - |
dc.contributor.googleauthor | WON-JUNG KOH | - |
dc.contributor.googleauthor | KYUNG CHAN KIM | - |
dc.contributor.googleauthor | YEE HYUNG KIM | - |
dc.contributor.googleauthor | KWANG HA YOO | - |
dc.contributor.googleauthor | SEUNG HEON LEE | - |
dc.contributor.googleauthor | JAE-JOON YIM | - |
dc.contributor.googleauthor | SANG BONG CHOI | - |
dc.contributor.googleauthor | WON-IL CHOI | - |
dc.contributor.googleauthor | JAE CHOL CHOI | - |
dc.contributor.googleauthor | YONG IL HWANG | - |
dc.contributor.googleauthor | TAE SUN SHIM | - |
dc.identifier.doi | 10.1111/j.1440-1843.2012.02218.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00057 | - |
dc.relation.journalcode | J02617 | - |
dc.identifier.eissn | 1440-1843 | - |
dc.identifier.pmid | 22758779 | - |
dc.subject.keyword | close contact | - |
dc.subject.keyword | interferon-g assay | - |
dc.subject.keyword | multi-drug-resistant tuberculosis | - |
dc.subject.keyword | tuberculin skin test | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | Kang, Young Ae | - |
dc.citation.volume | 17 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1125 | - |
dc.citation.endPage | 1130 | - |
dc.identifier.bibliographicCitation | RESPIROLOGY, Vol.17(7) : 1125-1130, 2012 | - |
dc.identifier.rimsid | 31194 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.