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Poor prediction of potentially drug-resistant pathogens using current criteria of health care-associated pneumonia

 Seon Cheol Park  ;  Young Ae Kang  ;  Byung Hoon Park  ;  Eun Young Kim  ;  Moo Suk Park  ;  Young Sam Kim  ;  Se Kyu Kim  ;  Joon Chang  ;  Ji Ye Jung 
 Respiratory Medicine, Vol.106(9) : 1311-1319, 2012 
Journal Title
 Respiratory Medicine 
Issue Date
BACKGROUND: Health care-associated pneumonia (HCAP) includes a broad range of patients having frequent or chronic contact with health care systems. However, the relationship between current defining criteria for HCAP and the risk of potentially drug-resistant (PDR) pathogens is controversial. METHODS: We retrospectively evaluated patients admitted to Severance Hospital in South Korea with culture-positive pneumonia from January 2008 to December 2009. We analyzed the associations between risk factors for HCAP and infection with PDR pathogens, and developed a new scoring system to predict infection with PDR pathogens. RESULTS: Among 339 patients, PDR pathogens were observed in 122 (36.0%). PDR pathogens were more common in HCAP than community-acquired pneumonia (CAP) (48.5% versus 23.8%, P<0.001). In a logistic regression, prior hospitalization within 90 days of pneumonia (OR=2.51, P=0.003), recent treatment with antimicrobials (OR=2.35, P=0.039), and nasogastric tube feeding (OR=15.28, P<0.001) were independently associated with PDR pathogens. For the prediction of PDR pathogens, the sensitivity and specificity of current HCAP criteria were 66.4% and 60.4%, respectively, and 68.0% and 67.3%, respectively, for the new scoring system. Moreover, the new scoring system showed better diagnostic accuracy than current HCAP criteria (area under curve=0.711 versus 0.634, P<0.001). CONCLUSIONS: The current HCAP criteria are poor predictors of PDR pathogens and all patients with HCAP should not be empirically treated for these pathogens. To avoid excessive antibiotic use, individual risk stratification approaches should be considered.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강영애(Kang, Young Ae) ; 김세규(Kim, Se Kyu) ; 김영삼(Kim, Young Sam) ; 김은영(Kim, Eun Young) ; 박무석(Park, Moo Suk) ; 박병훈(Park, Byung Hoon) ; 박선철(Park, Seon Cheol) ; 장준(Chang, Joon) ; 정지예(Jung, Ji Ye)
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