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Diagnostic performance of gray-scale US and elastography in solid thyroid nodules

DC FieldValueLanguage
dc.contributor.author곽진영-
dc.contributor.author김은경-
dc.contributor.author문희정-
dc.contributor.author성지민-
dc.contributor.author육지현-
dc.contributor.author윤정현-
dc.date.accessioned2014-12-19T17:38:01Z-
dc.date.available2014-12-19T17:38:01Z-
dc.date.issued2012-
dc.identifier.issn0033-8419-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91777-
dc.description.abstractPURPOSE: To evaluate the diagnostic performance of gray-scale ultrasonography (US) and elastography in differentiating benign and malignant thyroid nodules. MATERIALS AND METHODS: This was an institutional review board-approved retrospective study with waiver of informed consent. A total of 703 solid thyroid nodules in 676 patients (mean age, 49.7 years; range, 18-79 years) were included; there were 556 women (mean age, 49.5 years; range, 20-74 years) and 120 men (mean age, 50.7 years; range, 18-79 years). Nodules with marked hypoechogenicity, poorly defined margins, microcalcifications, and a taller-than-wide shape were classified as suspicious at grayscale US. Findings at elastography were classified according to the Rago criteria and the Asteria criteria. The diagnostic performances of gray-scale US and elastography were compared. For comparison between the diagnostic performances of gray-scale US and the combination of gray-scale US and elastography, three sets of criteria were assigned: criteria set 1, nodules with any suspicious grayscale US feature were assessed as suspicious; criteria set 2, Rago criteria were added as suspicious features to criteria set 1; and criteria set 3, Asteria criteria were added as suspicious features to criteria set 1. The diagnostic performances of gray-scale US, elastography with Rago criteria, and elastography with Asteria criteria, and odds ratios (ORs) with 95% confidence intervals for predicting thyroid malignancy were compared using generalized estimating equation analysis. RESULTS: Of 703 nodules, 217 were malignant and 486 were benign. Sensitivity, negative predictive value (NPV), and OR of gray-scale US for the 703 nodules were 91.7%, 94.7%, and 22.1, respectively, and these values were higher than the 15.7% and 65.4% sensitivity, 71.7% and 79.1% NPV, and 3.7 and 2.6 ORs found for elastography with Rago and Asteria criteria, respectively. Specificity, positive predictive value, and accuracy for criteria set 1 were significantly higher than those for criteria sets 2 and 3 for most of the nodule subgroups that were considered. CONCLUSION: Elastography alone, as well as the combination of elastography and gray-scale US, showed inferior performance in the differentiation of malignant and benign thyroid nodules compared with gray-scale US features; elastography was not a useful tool in recommending fine-needle aspiration biopsy.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfRADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiopsy-
dc.subject.MESHDiagnosis, Differential-
dc.subject.MESHElasticity Imaging Techniques/methods*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHThyroid Nodule/diagnostic imaging*-
dc.subject.MESHThyroid Nodule/pathology-
dc.subject.MESHUltrasonography, Interventional-
dc.titleDiagnostic performance of gray-scale US and elastography in solid thyroid nodules-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorHee Jung Moon-
dc.contributor.googleauthorJi Min Sung-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorJung Hyun Yoon-
dc.contributor.googleauthorJi Hyun Youk-
dc.contributor.googleauthorJin Young Kwak-
dc.identifier.doi22357900-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00182-
dc.contributor.localIdA00801-
dc.contributor.localIdA01397-
dc.contributor.localIdA02537-
dc.contributor.localIdA02595-
dc.contributor.localIdA01955-
dc.relation.journalcodeJ02596-
dc.identifier.eissn1527-1315-
dc.identifier.pmid22357900-
dc.subject.keywordAdolescent-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordBiopsy-
dc.subject.keywordDiagnosis, Differential-
dc.subject.keywordElasticity Imaging Techniques/methods*-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordLogistic Models-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordPredictive Value of Tests-
dc.subject.keywordRetrospective Studies-
dc.subject.keywordSensitivity and Specificity-
dc.subject.keywordThyroid Nodule/diagnostic imaging*-
dc.subject.keywordThyroid Nodule/pathology-
dc.subject.keywordUltrasonography, Interventional-
dc.contributor.alternativeNameKwak, Jin Young-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.alternativeNameMoon, Heui Jeong-
dc.contributor.alternativeNameSung, Ji Min-
dc.contributor.alternativeNameYouk, Ji Hyun-
dc.contributor.alternativeNameYoon, Jung Hyun-
dc.contributor.affiliatedAuthorKwak, Jin Young-
dc.contributor.affiliatedAuthorKim, Eun-Kyung-
dc.contributor.affiliatedAuthorMoon, Heui Jeong-
dc.contributor.affiliatedAuthorYouk, Ji Hyun-
dc.contributor.affiliatedAuthorYoon, Jung Hyun-
dc.contributor.affiliatedAuthorSung, Ji Min-
dc.citation.volume262-
dc.citation.number3-
dc.citation.startPage1002-
dc.citation.endPage1013-
dc.identifier.bibliographicCitationRADIOLOGY, Vol.262(3) : 1002-1013, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers

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