173 241

Cited 0 times in

Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B

Authors
 Beom Kyung Kim  ;  Seung Up Kim  ;  Hyon Suk Kim  ;  Jun Yong Park  ;  Sang Hoon Ahn  ;  Chae Yoon Chon  ;  In Rae Cho  ;  Dong-Hoo Joh  ;  Young Nyun Park  ;  Kwang-Hyub Han  ;  Do Young Kim 
Citation
 PLOS ONE, Vol.7(4) : e35825, 2012 
Journal Title
 PLOS ONE 
Issue Date
2012
MeSH
Adult ; Apolipoprotein A-I/blood ; Area Under Curve ; Asian Continental Ancestry Group ; Bilirubin/blood ; Biomarkers/blood ; Biomarkers/metabolism ; Biopsy ; Elasticity ; Elasticity Imaging Techniques ; Female ; Haptoglobins/metabolism ; Hepatitis B virus ; Hepatitis B, Chronic/complications* ; Hepatitis B, Chronic/pathology ; Humans ; Liver/pathology ; Liver/virology ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnosis* ; Liver Cirrhosis/virology ; Male ; Middle Aged ; Prospective Studies ; ROC Curve ; alpha-Macroglobulins/metabolism ; gamma-Glutamyltransferase/blood
Keywords
Adult ; Apolipoprotein A-I/blood ; Area Under Curve ; Asian Continental Ancestry Group ; Bilirubin/blood ; Biomarkers/blood ; Biomarkers/metabolism ; Biopsy ; Elasticity ; Elasticity Imaging Techniques ; Female ; Haptoglobins/metabolism ; Hepatitis B virus ; Hepatitis B, Chronic/complications* ; Hepatitis B, Chronic/pathology ; Humans ; Liver/pathology ; Liver/virology ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnosis* ; Liver Cirrhosis/virology ; Male ; Middle Aged ; Prospective Studies ; ROC Curve ; alpha-Macroglobulins/metabolism ; gamma-Glutamyltransferase/blood
Abstract
BACKGROUND AND AIMS: Diagnostic values of FibroTest (FT) for hepatic fibrosis have rarely been assessed in Asian chronic hepatitis B (CHB) patients. We aimed to validate its diagnostic performances in comparison with liver stiffness (LS). METHODS: From 2008 to 2010, 194 CHB patients who underwent liver biopsies along with FT and transient elastography were prospectively enrolled. Fibrosis stage was assessed according to the Batts and Ludwig system. RESULTS: To predict significant fibrosis (F≥2), advanced fibrosis (F≥3), and cirrhosis (F = 4), areas under receiver operating characteristic curves (AUROCs) of FT were 0.903, 0.907, and 0.866, comparable to those of LS (0.873, 0.897, and 0.910, respectively). Optimized cutoffs of FT to maximize sum of sensitivity and specificity were 0.32, 0.52, and 0.68 for F≥2, F≥3, and F = 4, while those of LS were 8.8, 10.2, and 14.1 kPa, respectively. According to FT and LS cutoffs, 123 (63.4%) and 124 (63.9%) patients were correctly classified consistent with histological fibrosis (F1, F2, F3, and F4), respectively. Overall concordance between each fibrosis stage estimated by FT and LS was observed in 111 patients, where 88 were correctly classified with histological results. A combination formula adding LS to FT (LS+FT) showed similar AUROC levels (0.885, 0.905, and 0.915), while another multiplying LS by FT (LS×FT) showed the best AUROCs (0.941, 0.931, and 0.929 for F≥2, F≥3, and F4, respectively). CONCLUSIONS: FT provides good fibrosis prediction, with comparable outcomes to LS in Asian CHB patients. FT substantially reduces need for liver biopsy, especially when used in combination with LS.
Files in This Item:
T201201798.pdf Download
DOI
22536445
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Chon, Chae Yoon(전재윤)
Joh, Dong Hoo(조동후)
Cho, In Rae(조인래)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91687
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse