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Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B
DC Field | Value | Language |
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dc.contributor.author | 안상훈 | - |
dc.contributor.author | 전재윤 | - |
dc.contributor.author | 조동후 | - |
dc.contributor.author | 김도영 | - |
dc.contributor.author | 조인래 | - |
dc.contributor.author | 김범경 | - |
dc.contributor.author | 한광협 | - |
dc.contributor.author | 김승업 | - |
dc.contributor.author | 김현숙 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 박준용 | - |
dc.date.accessioned | 2014-12-19T17:35:11Z | - |
dc.date.available | 2014-12-19T17:35:11Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91687 | - |
dc.description.abstract | BACKGROUND AND AIMS: Diagnostic values of FibroTest (FT) for hepatic fibrosis have rarely been assessed in Asian chronic hepatitis B (CHB) patients. We aimed to validate its diagnostic performances in comparison with liver stiffness (LS). METHODS: From 2008 to 2010, 194 CHB patients who underwent liver biopsies along with FT and transient elastography were prospectively enrolled. Fibrosis stage was assessed according to the Batts and Ludwig system. RESULTS: To predict significant fibrosis (F≥2), advanced fibrosis (F≥3), and cirrhosis (F = 4), areas under receiver operating characteristic curves (AUROCs) of FT were 0.903, 0.907, and 0.866, comparable to those of LS (0.873, 0.897, and 0.910, respectively). Optimized cutoffs of FT to maximize sum of sensitivity and specificity were 0.32, 0.52, and 0.68 for F≥2, F≥3, and F = 4, while those of LS were 8.8, 10.2, and 14.1 kPa, respectively. According to FT and LS cutoffs, 123 (63.4%) and 124 (63.9%) patients were correctly classified consistent with histological fibrosis (F1, F2, F3, and F4), respectively. Overall concordance between each fibrosis stage estimated by FT and LS was observed in 111 patients, where 88 were correctly classified with histological results. A combination formula adding LS to FT (LS+FT) showed similar AUROC levels (0.885, 0.905, and 0.915), while another multiplying LS by FT (LS×FT) showed the best AUROCs (0.941, 0.931, and 0.929 for F≥2, F≥3, and F4, respectively). CONCLUSIONS: FT provides good fibrosis prediction, with comparable outcomes to LS in Asian CHB patients. FT substantially reduces need for liver biopsy, especially when used in combination with LS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e35825 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Apolipoprotein A-I/blood | - |
dc.subject.MESH | Area Under Curve | - |
dc.subject.MESH | Asian Continental Ancestry Group | - |
dc.subject.MESH | Bilirubin/blood | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Biomarkers/metabolism | - |
dc.subject.MESH | Biopsy | - |
dc.subject.MESH | Elasticity | - |
dc.subject.MESH | Elasticity Imaging Techniques | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Haptoglobins/metabolism | - |
dc.subject.MESH | Hepatitis B virus | - |
dc.subject.MESH | Hepatitis B, Chronic/complications* | - |
dc.subject.MESH | Hepatitis B, Chronic/pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver/pathology | - |
dc.subject.MESH | Liver/virology | - |
dc.subject.MESH | Liver Cirrhosis/blood | - |
dc.subject.MESH | Liver Cirrhosis/diagnosis* | - |
dc.subject.MESH | Liver Cirrhosis/virology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | alpha-Macroglobulins/metabolism | - |
dc.subject.MESH | gamma-Glutamyltransferase/blood | - |
dc.title | Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Beom Kyung Kim | - |
dc.contributor.googleauthor | Seung Up Kim | - |
dc.contributor.googleauthor | Hyon Suk Kim | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Chae Yoon Chon | - |
dc.contributor.googleauthor | In Rae Cho | - |
dc.contributor.googleauthor | Dong-Hoo Joh | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.identifier.doi | 22536445 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A03815 | - |
dc.contributor.localId | A03890 | - |
dc.contributor.localId | A00487 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A03544 | - |
dc.contributor.localId | A01117 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 22536445 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Apolipoprotein A-I/blood | - |
dc.subject.keyword | Area Under Curve | - |
dc.subject.keyword | Asian Continental Ancestry Group | - |
dc.subject.keyword | Bilirubin/blood | - |
dc.subject.keyword | Biomarkers/blood | - |
dc.subject.keyword | Biomarkers/metabolism | - |
dc.subject.keyword | Biopsy | - |
dc.subject.keyword | Elasticity | - |
dc.subject.keyword | Elasticity Imaging Techniques | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Haptoglobins/metabolism | - |
dc.subject.keyword | Hepatitis B virus | - |
dc.subject.keyword | Hepatitis B, Chronic/complications* | - |
dc.subject.keyword | Hepatitis B, Chronic/pathology | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Liver/pathology | - |
dc.subject.keyword | Liver/virology | - |
dc.subject.keyword | Liver Cirrhosis/blood | - |
dc.subject.keyword | Liver Cirrhosis/diagnosis* | - |
dc.subject.keyword | Liver Cirrhosis/virology | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Prospective Studies | - |
dc.subject.keyword | ROC Curve | - |
dc.subject.keyword | alpha-Macroglobulins/metabolism | - |
dc.subject.keyword | gamma-Glutamyltransferase/blood | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Chon, Chae Yoon | - |
dc.contributor.alternativeName | Joh, Dong Hoo | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Cho, In Rae | - |
dc.contributor.alternativeName | Kim, Beom Kyung | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Joh, Dong Hoo | - |
dc.contributor.affiliatedAuthor | Cho, In Rae | - |
dc.contributor.affiliatedAuthor | Kim, Beom Kyung | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Chon, Chae Yoon | - |
dc.contributor.affiliatedAuthor | Kim, Hyon Suk | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.citation.volume | 7 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | e35825 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.7(4) : e35825, 2012 | - |
dc.identifier.rimsid | 29561 | - |
dc.type.rims | ART | - |
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