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Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model

Authors
 Jeong-Hyun Lee  ;  Hye-Lee Kim  ;  Mi Hee Lee  ;  Kyung Eun You  ;  yeong-Ju Kwon  ;  Hyok Jin Seo  ;  Jong-Chul Park 
Citation
 PHYTOMEDICINE, Vol.19(13) : 1223-1227, 2012 
Journal Title
 PHYTOMEDICINE 
ISSN
 0944-7113 
Issue Date
2012
MeSH
Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Drug Evaluation, Preclinical ; Fibroblasts/drug effects* ; Humans ; Phytotherapy* ; Triterpenes/pharmacology* ; Wound Healing/drug effects*
Keywords
Cutaneous wound repair ; Centella asiatica ; Asiaticoside ; Human dermal fibroblast ; Human epidermal keratinocyte
Abstract
Wound healing proceeds through a complex collaborative process involving many types of cells. Keratinocytes and fibroblasts of epidermal and dermal layers of the skin play prominent roles in this process. Asiaticoside, an active component of Centella asiatica, is known for beneficial effects on keloid and hypertrophic scar. However, the effects of this compound on normal human skin cells are not well known. Using in vitro systems, we observed the effects of asiaticoside on normal human skin cell behaviors related to healing. In a wound closure seeding model, asiaticoside increased migration rates of skin cells. By observing the numbers of cells attached and the area occupied by the cells, we concluded that asiaticoside also enhanced the initial skin cell adhesion. In cell proliferation assays, asiaticoside induced an increase in the number of normal human dermal fibroblasts. In conclusion, asiaticoside promotes skin cell behaviors involved in wound healing; and as a bioactive component of an artificial skin, may have therapeutic value.
Full Text
http://www.sciencedirect.com/science/article/pii/S0944711312002516
DOI
22939261
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Byeong-Ju(권병주) ORCID logo https://orcid.org/0000-0001-9916-0546
Kim, Hye Lee(김혜리)
You, Kyung Eun(류경은)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Seo, Hyok Jin(서혁진)
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
Lee, Jeong Hyun(이정현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91666
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