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Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model

Authors
 Jeong-Hyun Lee  ;  Hye-Lee Kim  ;  Mi Hee Lee  ;  Kyung Eun You  ;  yeong-Ju Kwon  ;  Hyok Jin Seo  ;  Jong-Chul Park 
Citation
 Phytomedicine, Vol.19(13) : 1223-1227, 2012 
Journal Title
 Phytomedicine 
ISSN
 0944-7113 
Issue Date
2012
Abstract
Wound healing proceeds through a complex collaborative process involving many types of cells. Keratinocytes and fibroblasts of epidermal and dermal layers of the skin play prominent roles in this process. Asiaticoside, an active component of Centella asiatica, is known for beneficial effects on keloid and hypertrophic scar. However, the effects of this compound on normal human skin cells are not well known. Using in vitro systems, we observed the effects of asiaticoside on normal human skin cell behaviors related to healing. In a wound closure seeding model, asiaticoside increased migration rates of skin cells. By observing the numbers of cells attached and the area occupied by the cells, we concluded that asiaticoside also enhanced the initial skin cell adhesion. In cell proliferation assays, asiaticoside induced an increase in the number of normal human dermal fibroblasts. In conclusion, asiaticoside promotes skin cell behaviors involved in wound healing; and as a bioactive component of an artificial skin, may have therapeutic value.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91666
Full Text
http://www.sciencedirect.com/science/article/pii/S0944711312002516
DOI
10.1016/j.phymed.2012.08.002
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실)
Yonsei Authors
권병주(Kwon, Byeong-Ju)
김혜리(Kim, Hye Lee)
류경은(You, Kyung Eun)
박종철(Park, Jong Chul) ORCID logo https://orcid.org/0000-0003-0083-5991
서혁진(Seo, Hyok Jin)
이미희(Lee, Mi Hee) ORCID logo https://orcid.org/0000-0002-9630-7044
이정현(Lee, Jeong Hyun)
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