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Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model

DC FieldValueLanguage
dc.contributor.author권병주-
dc.contributor.author김혜리-
dc.contributor.author류경은-
dc.contributor.author박종철-
dc.contributor.author서혁진-
dc.contributor.author이미희-
dc.contributor.author이정현-
dc.date.accessioned2014-12-19T17:34:30Z-
dc.date.available2014-12-19T17:34:30Z-
dc.date.issued2012-
dc.identifier.issn0944-7113-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91666-
dc.description.abstractWound healing proceeds through a complex collaborative process involving many types of cells. Keratinocytes and fibroblasts of epidermal and dermal layers of the skin play prominent roles in this process. Asiaticoside, an active component of Centella asiatica, is known for beneficial effects on keloid and hypertrophic scar. However, the effects of this compound on normal human skin cells are not well known. Using in vitro systems, we observed the effects of asiaticoside on normal human skin cell behaviors related to healing. In a wound closure seeding model, asiaticoside increased migration rates of skin cells. By observing the numbers of cells attached and the area occupied by the cells, we concluded that asiaticoside also enhanced the initial skin cell adhesion. In cell proliferation assays, asiaticoside induced an increase in the number of normal human dermal fibroblasts. In conclusion, asiaticoside promotes skin cell behaviors involved in wound healing; and as a bioactive component of an artificial skin, may have therapeutic value.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPHYTOMEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCell Movement/drug effects-
dc.subject.MESHCell Proliferation/drug effects-
dc.subject.MESHCells, Cultured-
dc.subject.MESHDrug Evaluation, Preclinical-
dc.subject.MESHFibroblasts/drug effects*-
dc.subject.MESHHumans-
dc.subject.MESHPhytotherapy*-
dc.subject.MESHTriterpenes/pharmacology*-
dc.subject.MESHWound Healing/drug effects*-
dc.titleAsiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학)-
dc.contributor.googleauthorJeong-Hyun Lee-
dc.contributor.googleauthorHye-Lee Kim-
dc.contributor.googleauthorMi Hee Lee-
dc.contributor.googleauthorKyung Eun You-
dc.contributor.googleauthoryeong-Ju Kwon-
dc.contributor.googleauthorHyok Jin Seo-
dc.contributor.googleauthorJong-Chul Park-
dc.identifier.doi22939261-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00218-
dc.contributor.localIdA01169-
dc.contributor.localIdA01319-
dc.contributor.localIdA01662-
dc.contributor.localIdA01922-
dc.contributor.localIdA03127-
dc.contributor.localIdA02777-
dc.relation.journalcodeJ02530-
dc.identifier.eissn1618-095X-
dc.identifier.pmid22939261-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0944711312002516-
dc.subject.keywordCutaneous wound repair-
dc.subject.keywordCentella asiatica-
dc.subject.keywordAsiaticoside-
dc.subject.keywordHuman dermal fibroblast-
dc.subject.keywordHuman epidermal keratinocyte-
dc.contributor.alternativeNameKwon, Byeong Ju-
dc.contributor.alternativeNameKim, Hye Lee-
dc.contributor.alternativeNameYou, Kyung Eun-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.alternativeNameSeo, Hyok Jin-
dc.contributor.alternativeNameLee, Mi Hee-
dc.contributor.alternativeNameLee, Jeong Hyun-
dc.contributor.affiliatedAuthorKwon, Byeong Ju-
dc.contributor.affiliatedAuthorKim, Hye Lee-
dc.contributor.affiliatedAuthorYou, Kyung Eun-
dc.contributor.affiliatedAuthorPark, Jong Chul-
dc.contributor.affiliatedAuthorSeo, Hyok Jin-
dc.contributor.affiliatedAuthorLee, Jeong Hyun-
dc.contributor.affiliatedAuthorLee, Mi Hee-
dc.citation.volume19-
dc.citation.number13-
dc.citation.startPage1223-
dc.citation.endPage1227-
dc.identifier.bibliographicCitationPHYTOMEDICINE, Vol.19(13) : 1223-1227, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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