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Hypoxia-specific VEGF-expressing neural stem cells in spinal cord injury model

Authors
 Oh, Jin Soo  ;  An, Sung Su  ;  Gwak, So-Jung  ;  Pennant, William A.  ;  Kim, Keung Nyun  ;  Yoon, Do Heum  ;  Ha, Yoon 
Citation
 NEUROREPORT, Vol.23(3) : 174-178, 2012 
Journal Title
 NEUROREPORT 
ISSN
 0959-4965 
Issue Date
2012
MeSH
Animals ; Cell Hypoxia ; Cell Line ; Cell Proliferation ; Disease Models, Animal ; Gene Expression ; Gene Expression Regulation ; Genetic Therapy/methods ; Male ; Mice ; Neural Stem Cells/cytology ; Neural Stem Cells/transplantation* ; Neurons/metabolism ; Rats ; Rats, Sprague-Dawley ; Spinal Cord Injuries/metabolism ; Spinal Cord Injuries/therapy* ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism*
Keywords
efficacy ; hypoxia-specific gene expression ; neural stem cells ; safety ; vascular endothelial growth factor
Abstract
We established three stable neural stem cell (NSC) lines to explore the possibility of using hypoxia-specific vascular endothelial growth factor (VEGF) expressing NSC lines (EpoSV-VEGF NSCs) to treat spinal cord injury. The application of EpoSV-VEGF NSCs into the injured spinal cord after clip compression injury not only showed therapeutic effects such as extended survival and angiogenesis, but also displayed its safety profile as it did not cause unwanted cell proliferation or angiogenesis in normal spinal cord tissue, as EpoSV-VEGF NSCs consistently showed hypoxia-specific VEGF expression patterns. This suggests that our EpoSV-VEGF NSCs are both safe and therapeutically efficacious for the treatment of spinal cord injury. Furthermore, this hypoxia-inducible gene expression system may represent a safe tool suitable for gene therapy.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201202150-00010&LSLINK=80&D=ovft
DOI
22186804
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Gwak, So Jung(곽소정)
Kim, Keung Nyun(김긍년)
An, Sung Su(안성수)
Oh, Jin Soo(오진수)
Yoon, Do Heum(윤도흠) ORCID logo https://orcid.org/0000-0003-1452-5724
Ha, Yoon(하윤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91542
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