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Hypoxia-specific VEGF-expressing neural stem cells in spinal cord injury model

Authors
 Oh, Jin Soo  ;  An, Sung Su  ;  Gwak, So-Jung  ;  Pennant, William A.  ;  Kim, Keung Nyun  ;  Yoon, Do Heum  ;  Ha, Yoon 
Citation
 Neuroreport, Vol.23(3) : 174-178, 2012 
Journal Title
 Neuroreport 
ISSN
 0959-4965 
Issue Date
2012
Abstract
We established three stable neural stem cell (NSC) lines to explore the possibility of using hypoxia-specific vascular endothelial growth factor (VEGF) expressing NSC lines (EpoSV-VEGF NSCs) to treat spinal cord injury. The application of EpoSV-VEGF NSCs into the injured spinal cord after clip compression injury not only showed therapeutic effects such as extended survival and angiogenesis, but also displayed its safety profile as it did not cause unwanted cell proliferation or angiogenesis in normal spinal cord tissue, as EpoSV-VEGF NSCs consistently showed hypoxia-specific VEGF expression patterns. This suggests that our EpoSV-VEGF NSCs are both safe and therapeutically efficacious for the treatment of spinal cord injury. Furthermore, this hypoxia-inducible gene expression system may represent a safe tool suitable for gene therapy.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91542
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201202150-00010&LSLINK=80&D=ovft
DOI
10.1097/WNR.0b013e32834f4f3a
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
Yonsei Authors
곽소정(Gwak, So Jung)
김긍년(Kim, Keung Nyun)
안성수(An, Sung Su)
오진수(Oh, Jin Soo)
윤도흠(Yoon, Do Heum)
하윤(Ha, Yoon)
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