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Hypoxia-specific VEGF-expressing neural stem cells in spinal cord injury model

DC FieldValueLanguage
dc.contributor.author곽소정-
dc.contributor.author김긍년-
dc.contributor.author안성수-
dc.contributor.author오진수-
dc.contributor.author윤도흠-
dc.contributor.author하윤-
dc.date.accessioned2014-12-19T17:30:36Z-
dc.date.available2014-12-19T17:30:36Z-
dc.date.issued2012-
dc.identifier.issn0959-4965-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91542-
dc.description.abstractWe established three stable neural stem cell (NSC) lines to explore the possibility of using hypoxia-specific vascular endothelial growth factor (VEGF) expressing NSC lines (EpoSV-VEGF NSCs) to treat spinal cord injury. The application of EpoSV-VEGF NSCs into the injured spinal cord after clip compression injury not only showed therapeutic effects such as extended survival and angiogenesis, but also displayed its safety profile as it did not cause unwanted cell proliferation or angiogenesis in normal spinal cord tissue, as EpoSV-VEGF NSCs consistently showed hypoxia-specific VEGF expression patterns. This suggests that our EpoSV-VEGF NSCs are both safe and therapeutically efficacious for the treatment of spinal cord injury. Furthermore, this hypoxia-inducible gene expression system may represent a safe tool suitable for gene therapy.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfNEUROREPORT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCell Hypoxia-
dc.subject.MESHCell Line-
dc.subject.MESHCell Proliferation-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHGene Expression-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHGenetic Therapy/methods-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHNeural Stem Cells/cytology-
dc.subject.MESHNeural Stem Cells/transplantation*-
dc.subject.MESHNeurons/metabolism-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHSpinal Cord Injuries/metabolism-
dc.subject.MESHSpinal Cord Injuries/therapy*-
dc.subject.MESHVascular Endothelial Growth Factor A/genetics-
dc.subject.MESHVascular Endothelial Growth Factor A/metabolism*-
dc.titleHypoxia-specific VEGF-expressing neural stem cells in spinal cord injury model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorOh, Jin Soo-
dc.contributor.googleauthorAn, Sung Su-
dc.contributor.googleauthorGwak, So-Jung-
dc.contributor.googleauthorPennant, William A.-
dc.contributor.googleauthorKim, Keung Nyun-
dc.contributor.googleauthorYoon, Do Heum-
dc.contributor.googleauthorHa, Yoon-
dc.identifier.doi22186804-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00168-
dc.contributor.localIdA00331-
dc.contributor.localIdA02235-
dc.contributor.localIdA02401-
dc.contributor.localIdA02546-
dc.contributor.localIdA04255-
dc.relation.journalcodeJ02361-
dc.identifier.eissn1473-558X-
dc.identifier.pmid22186804-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201202150-00010&LSLINK=80&D=ovft-
dc.subject.keywordefficacy-
dc.subject.keywordhypoxia-specific gene expression-
dc.subject.keywordneural stem cells-
dc.subject.keywordsafety-
dc.subject.keywordvascular endothelial growth factor-
dc.contributor.alternativeNameGwak, So Jung-
dc.contributor.alternativeNameKim, Keung Nyun-
dc.contributor.alternativeNameAn, Sung Su-
dc.contributor.alternativeNameOh, Jin Soo-
dc.contributor.alternativeNameYoon, Do Heum-
dc.contributor.alternativeNameHa, Yoon-
dc.contributor.affiliatedAuthorGwak, So Jung-
dc.contributor.affiliatedAuthorKim, Keung Nyun-
dc.contributor.affiliatedAuthorAn, Sung Su-
dc.contributor.affiliatedAuthorOh, Jin Soo-
dc.contributor.affiliatedAuthorYoon, Do Heum-
dc.contributor.affiliatedAuthorHa, Yoon-
dc.citation.volume23-
dc.citation.number3-
dc.citation.startPage174-
dc.citation.endPage178-
dc.identifier.bibliographicCitationNEUROREPORT, Vol.23(3) : 174-178, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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