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A magnetic switch for the control of cell death signalling in in vitro and in vivo systems

Authors
 Mi Hyeon Cho  ;  Eun Jung Lee  ;  Mina Son  ;  Jae-Hyun Lee  ;  Dongwon Yoo  ;  Ji-wook Kim  ;  Seung Woo Park  ;  Jeon-Soo Shin  ;  Jinwoo Cheon 
Citation
 Nature Materials, Vol.11(12) : 1038-1043, 2012 
Journal Title
 Nature Materials 
ISSN
 1476-1122 
Issue Date
2012
MeSH
Animals ; Apoptosis/physiology* ; Cell Death/physiology ; Cells, Cultured ; Magnetite Nanoparticles* ; Signal Transduction* ; Zebrafish
Keywords
Animals ; Apoptosis/physiology* ; Cell Death/physiology ; Cells, Cultured ; Magnetite Nanoparticles* ; Signal Transduction* ; Zebrafish
Abstract
The regulation of cellular activities in a controlled manner is one of the most challenging issues in fields ranging from cell biology to biomedicine. Nanoparticles have the potential of becoming useful tools for controlling cell signalling pathways in a space and time selective fashion. Here, we have developed magnetic nanoparticles that turn on apoptosis cell signalling by using a magnetic field in a remote and non-invasive manner. The magnetic switch consists of zinc-doped iron oxide magnetic nanoparticles (Zn(0.4)Fe(2.6)O(4)), conjugated with a targeting antibody for death receptor 4 (DR4) of DLD-1 colon cancer cells. The magnetic switch, in its On mode when a magnetic field is applied to aggregate magnetic nanoparticle-bound DR4s, promotes apoptosis signalling pathways. We have also demonstrated that the magnetic switch is operable at the micrometre scale and that it can be applied in an in vivo system where apoptotic morphological changes of zebrafish are successfully induced.
Full Text
http://www.nature.com/nmat/journal/v11/n12/full/nmat3430.html
DOI
23042417
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91506
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