3 352

Cited 0 times in

A magnetic switch for the control of cell death signalling in in vitro and in vivo systems

DC FieldValueLanguage
dc.contributor.author박승우-
dc.contributor.author신전수-
dc.date.accessioned2014-12-19T17:29:27Z-
dc.date.available2014-12-19T17:29:27Z-
dc.date.issued2012-
dc.identifier.issn1476-1122-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91506-
dc.description.abstractThe regulation of cellular activities in a controlled manner is one of the most challenging issues in fields ranging from cell biology to biomedicine. Nanoparticles have the potential of becoming useful tools for controlling cell signalling pathways in a space and time selective fashion. Here, we have developed magnetic nanoparticles that turn on apoptosis cell signalling by using a magnetic field in a remote and non-invasive manner. The magnetic switch consists of zinc-doped iron oxide magnetic nanoparticles (Zn(0.4)Fe(2.6)O(4)), conjugated with a targeting antibody for death receptor 4 (DR4) of DLD-1 colon cancer cells. The magnetic switch, in its On mode when a magnetic field is applied to aggregate magnetic nanoparticle-bound DR4s, promotes apoptosis signalling pathways. We have also demonstrated that the magnetic switch is operable at the micrometre scale and that it can be applied in an in vivo system where apoptotic morphological changes of zebrafish are successfully induced.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfNATURE MATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis/physiology*-
dc.subject.MESHCell Death/physiology-
dc.subject.MESHCells, Cultured-
dc.subject.MESHMagnetite Nanoparticles*-
dc.subject.MESHSignal Transduction*-
dc.subject.MESHZebrafish-
dc.titleA magnetic switch for the control of cell death signalling in in vitro and in vivo systems-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorMi Hyeon Cho-
dc.contributor.googleauthorEun Jung Lee-
dc.contributor.googleauthorMina Son-
dc.contributor.googleauthorJae-Hyun Lee-
dc.contributor.googleauthorDongwon Yoo-
dc.contributor.googleauthorJi-wook Kim-
dc.contributor.googleauthorSeung Woo Park-
dc.contributor.googleauthorJeon-Soo Shin-
dc.contributor.googleauthorJinwoo Cheon-
dc.identifier.doi23042417-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01551-
dc.contributor.localIdA02144-
dc.relation.journalcodeJ02295-
dc.identifier.pmid23042417-
dc.identifier.urlhttp://www.nature.com/nmat/journal/v11/n12/full/nmat3430.html-
dc.subject.keywordAnimals-
dc.subject.keywordApoptosis/physiology*-
dc.subject.keywordCell Death/physiology-
dc.subject.keywordCells, Cultured-
dc.subject.keywordMagnetite Nanoparticles*-
dc.subject.keywordSignal Transduction*-
dc.subject.keywordZebrafish-
dc.contributor.alternativeNamePark, Seung Woo-
dc.contributor.alternativeNameShin, Jeon Soo-
dc.contributor.affiliatedAuthorPark, Seung Woo-
dc.contributor.affiliatedAuthorShin, Jeon Soo-
dc.citation.volume11-
dc.citation.number12-
dc.citation.startPage1038-
dc.citation.endPage1043-
dc.identifier.bibliographicCitationNATURE MATERIALS, Vol.11(12) : 1038-1043, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.