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Gelatin-layered and multi-sized porous β-tricalcium phosphate for tissue engineering scaffold

Authors
 Sung-Min Kim  ;  Soon-Aei Yi  ;  Seong-Ho Choi  ;  Kwang-Mahn Kim  ;  Yong-Keun Lee 
Citation
 Nanoscale Research Letters, Vol.7(1) : 78-78, 2012 
Journal Title
 Nanoscale Research Letters 
ISSN
 1931-7573 
Issue Date
2012
Abstract
The multi-sized porous β-tricalcium phosphate scaffolds were fabricated by freeze drying followed by slurry coating using a multi-sized porous sponge as a template. Then, gelatin was dip coated on the multi-sized porous β-tricalcium phosphate scaffolds under vacuum. The mechanical and biological properties of the fabricated scaffolds were evaluated and compared to the uniformly sized porous scaffolds and scaffolds that were not coated by gelatin. The compressive strength was tested by a universal testing machine, and the cell viability and differentiation behavior were measured using a cell counting kit and alkaline phosphatase activity using the MC3T3-E1 cells. In comparison, the gelatin-coated multi-sized porous β-tricalcium phosphate scaffold showed enhanced compressive strength. After 14 days, the multi-sized pores were shown to affect cell differentiation, and gelatin coatings were shown to affect the cell viability and differentiation. The results of this study demonstrated that the multi-sized porous β-tricalcium phosphate scaffold coated by gelatin enhanced the mechanical and biological strengths.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91489
DOI
10.1186/1556-276X-7-78
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실)
Yonsei Authors
김광만(Kim, Kwang Mahn) ; 김성민(Kim, Sung Min) ; 이순애(Yi, Soon Aei) ; 이용근(Lee, Yong Keun) ; 최성호(Choi, Seong Ho)
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